摘要
目的：应用氢质子磁共振波谱（1H-MRS）技术，分析正常中年人双侧海马在不同年龄组、不同部位各代谢物比值变化规律，为临床早期诊断及治疗海马相关性疾病提供参考依据。材料与方法从社区健康志愿者中选取符合标准者276名，按年龄分3组，A组：壮实期（41～48岁）90名，B组：稳健期（49～55岁）93名，C组：调整期（56～65岁）93名，行常规颅脑MR平扫、双侧海马MRS扫描，计算双侧海马头、体、尾部NAA/Cr、Cho/Cr、NAA/（Cho＋Cr）值，分析不同性别间、左右侧别间、各年龄组间及同年龄组不同部位间各参数的差异及各参数与年龄的相关性。结果 NAA/Cr、Cho/Cr、NAA/（Cho＋Cr）值在男女之间、左右侧别间差异无统计学意义（P＞0.05）；各年龄组间相同部位差异有统计学意义（P＜0.05），NAA/Cr、NAA/（Cho＋Cr）值A、B组均高于C组（P＜0.05），Cho/Cr值A组低于C组（P＜0.05）；NAA/Cr、Cho/Cr值在同年龄组不同部位间差异有统计学意义（P＜0.05），NAA/Cr值在A、B、C组海马头、体部均高于尾部（P＜0.05）， Cho/Cr值A、B组海马体部均高于尾部。NAA/Cr、NAA/（Cho＋Cr）值与年龄呈负相关（r值分别为－0.486、－0.653，P＜0.05）；Cho/Cr值与年龄呈正相关（r值为0.482，P＜0.05）。结论1H-MRS能反映正常中年人海马不同部位代谢物相对含量的变化，为早期临床诊断及治疗海马相关性疾病提供参考依据。
AbstractObjective：To discuss the changes of the brain metabolites on the bilateral hippocampus of different age groups and parts in normal chinese middle-aged group by using magnetic resonance spectroscopy （MRS）, to provide reference for early clinical diagnosis and treatment of hippocampal-related diseases.Materials and Methods： From community healthy volunteers, we selected 276 according to the standards, who were divided into three groups according to age, A group： prime period, 41 to 48 years, B group： steady period, 49 to 55 years, C group： adjustment period, 56 to 65 years, with about 100 subjects for each, underwent conventional cerebral MR scans, bilateral hippocampal MRS scans. The parameters of NAA/Cr, Cho/Cr, NAA/（Cho＋Cr） ratio were measured. To analyse the differences of the parameters between different genders, sides, groups and parts, and discuss the correlation between the parameters and age.Results：The ratios of NAA/Cr, Cho/Cr, NAA/（Cho＋Cr） had no signiifcant difference between genders and left-right sides （P〉0.05）. The ratios of metabolites had statistically significant difference among age groups （P〈0.05）, the ratio of NAA/Cr, NAA/（Cho＋Cr） was higher in group A, B than that in group C （P〈0.05）, the ratio of Cho/Cr was lower in group A than that in group C （P〈0.05）. The ratio of NAA/Cr, Cho/Cr had statistically significant difference between different parts （P〈0.05）. But, the ratio of NAA/（Cho＋Cr） had no signiifcant difference （P〉0.05）. The ratios of NAA/Cr, NAA/（Cho＋Cr） were negatively correlated with age （r value：-0.486,-0.653, P〈0.05）, the ratio of Cho/Cr was positively correlated with age （r value： 0.482,P〈0.05）.Conclusions：MRS could relfect varieties of hippocampal metabolites in normal chinese middle-aged people noninvasively, their combination could ifnd potential changes in micro metabolism and micro structure of normal brain and provide references for early clinical diagnosis of various diseases associated with hippocampus.
出处
《磁共振成像》
CAS
CSCD
2016年第9期651-656,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
山东省自然科学基金项目(编号:ZR2009CM115)~~
关键词
海马
代谢产物学
磁共振波谱学
成年人
Hippocampus
Metabolomics
Magnetic resonance spectroscopy
Adult
