摘要
目的 探讨联合用药治疗老年失代偿期乙肝后肝硬化患者的临床效果。方法 选取2012年3月~2014年4月于我院就诊的≥60岁的失代偿期乙肝后肝硬化患者62例。观察组32例采用拉米夫定联合阿德福韦酯治疗,对照组采用拉米夫定单药治疗。结果 观察组死亡4例。对照组死亡6例。治疗2年后观察组血清HBV DNA（t=2.583 9,P=0.009 8）、谷丙转氨酶（t=3.245 1,P=0.001 2）、总胆红素均低于对照组（t=2.627 1,P=0.008 6）,差异有统计学意义（P〈0.05）。结论 拉米夫定联合阿德福韦酯治疗老年性失代偿期乙肝后肝硬化效果更佳。
Objective To explore the clinical effect of combined medication in the treatment of elderly patients with chronic hepatitis B cirrhosis. Methods 62 cases more than 60 years old decompensated hepatitis B cirrhosis in our hospital from March 2012 to April 2014. The observation group of 32 cases were treated with lamivudine combined with adefovir dipivoxil treatment, the control group of 30 cases were treated with lamivudine. Results 4 cases were observed in the observation group. Control group of 6 cases of death. After 2 years of treatment, observation group, the serum levels of HBV DNA （t=2.583 9, P=0,009 8）, alanine aminotransferase （t=3.245 1, P=0.001 2）, total bilirubin were lower than those of the control group （t=2.627 1, P=0.008 6）. The difference was statistically significant （P〈0.05）. Conclusion Lamivudine combined with adefovir dipivoxil in the treatment of liver cirrhosis after hepatitis B better effect loss compensatory stage of senile.
出处
《中国继续医学教育》
2016年第26期182-183,共2页
China Continuing Medical Education
关键词
乙肝失代偿期肝硬化
老年
拉米夫定
阿德福韦酯
肝功能
Hepatitis B decompensated cirrhosis, Lamivudine, Elderly, Adefovir dipivoxil, Liver fimction
