1blulIer - Ladner U, Gay RE, Gay S. Activation of synovioeytes [J]. Curr Opin Rheumatol, 2000, 12(3) : 186 - 194.
2Yamanishi Y, Boyle DL, Green DR, et al. p53 tumor suppressor gene mutations in (ibrohlast - like synovioeytes from erosion syno- vium and nonerosion synovium in rheumatoid arthritis [ J ]. Arthri- tis Res Ther, 2005, 7(1) : R12 -R18.
3Matsumoto S, MUller- Ladner U, Gay RE, et al. Ultrastructural demonstration of apoptosis, Fas and Bcl - 2 expression of rheuma- toid synovial fibroblasts [ J ]. J Rheumatol, 1996, 23 ( 8 ) : 1345 - 1352.
5Georganas C, Liu H, Perlman H, et al. Regulation of IL - 6 and IL- 8 expression in rheumatoid arthritis syovial fibroblasts: the dominant role for NF - kappa B but not C/EBP beta or c - Jun [J]. J Immuuol, 2000, 165(12) : 7199 -7206.
6Miagkov AV, Kovalenko DV, Brown CE, et al. NF - kappa B ac- tivation provides the potential link between inflammation and hy- perplasia in the arthritic joint [ J ]. Proc Natl Acad Sci U S A, 1998, 95(23) : 13859 - 13864.
7Grabiee AM, Angiolilli C, Hartkamp LM, et al. JNK - dependent downregulation of FoxO1 is required to promote the survival of fi- broblast - like synoviocytes in rheumatoid arthritis [ J ]. Ann Rheum Dis, 2015, 74(9): 1763- 1771.
8Perlman H, Pagliari LJ, Liu H, et al. Rheumatoid arthritis syno- vial maerophages express the Fas -associated death domain -like interleukin - 1 beta - converting enzyme - inhibitory protein and are refractory to Fas - mediated apoptosis [ J ]. Arthritis Rheum, 2001, 44(1) : 21 -30.
9Meinecke I, Cinski A, Baier A, et al. Modification of nuclear PML protein by SUMO - 1 regulates Fas - induced apoptosis in rheumatoid arthritis synovial fibroblasts[J]. Proc Nad Acad Sci U S A, 2007, 104(12) : 5073 -5078.
10Li H, Wan A. Apoptosis of rheumatoid arthritis fibroblast - like synoviocytes: possible roles of nitric oxide and the thioredoxin 1 [J]. Mediators Inflamm, 2013: 953462.
4Dimmeler S, Zeiher AM. Endothelial cell apoptosis in angiogene- sis and vessel regression. Circ Res, 2000, 87: 434-439.
5Hida A, Kawakami A, Miyashita T, et al. Nitric oxide acts on the mitochondria and protects human endothelial cells from apop- tosis. J Lab Clin Med, 2004, 144: 148-155.
6Rominger CM, Bee WL, Copeland RA, et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther, 2009, 329: 995-1005.
7Thayer SP, di MMP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425: 851-856.
8Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature,2004, 431: 707-712.
9Berman DM, Karhadkar SS, Maitra A, et al. Widespread re- quirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 2003, 425: 846-851.
10Wilson CW, Chuang PT. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development, 2010, 137: 2079- 2094.
