摘要
目的:探讨注射用氟尿嘧啶对晚期胃癌患者亚甲基四氢叶酸还原酶、谷胱甘肽硫转移酶及肿瘤标志物的影响。方法:选取2014年5月—2015年11月三峡大学(宜昌市)第二人民医院收治的晚期胃癌患者83例。以随机数字表法分为卡培他滨组41例和氟尿嘧啶组42例。卡培他滨组患者给予卡培他滨为基础的化疗方案;氟尿嘧啶组给予注射用氟尿嘧啶为基础的化疗方案。比较2组患者的总有效率、不良反应发生率及干预前后亚甲基四氢叶酸还原酶、谷胱甘肽硫转移酶、肿瘤标志物水平的差异,观察2组患者治疗后生活质量。结果:治疗后,氟尿嘧啶组患者的总有效率明显高于卡培他滨组,不良反应发生率明显低于卡培他滨组,亚甲基四氢叶酸还原酶、谷胱甘肽硫转移酶、肿瘤标志物水平改善明显优于卡培他滨组,生活质量明显优于卡培他滨组,差异均有统计学意义(P<0.05)。结论:注射用氟尿嘧啶治疗晚期胃癌,效果确切,可有效改善患者亚甲基四氢叶酸还原酶、谷胱甘肽硫转移酶及肿瘤标志物水平,提高患者的生活质量,且不良反应较少。
OBJECTIVE： To probe into the effects of fluorouracil injections on methylenetetrahydrofolate reductase,glutathione s-transferase and tumor marker in patients with advanced gastric cancer. METHODS： 83 patients with advanced gastric cancer admitted into Three Gorges University（ Yichang） the Second People＇s Hospital from May 2014 to Nov. 2015 were selected to be divided into capecitabine group（ 41 cases） and fluorouracil group（ 42 cases） via the random number table. The capecitabine group were given chemotherapy regimen based on capecitabine; while the fluorouracil group received chemotherapy regimen based on fluorouracil. The total effective rate,incidence of adverse drug reactions and levels of methylenetetrahydrofolate reductase,glutathione s-transferase and tumor marker before and after treatment were compared between two groups; and the life quality was observed. RESULTS： After treatment,the total effective rate of fluorouracil group was significantly higher than that of capecitabine group,the incidence of adverse drug reactions was lower than that of capecitabine group, yet the improvement of levels of methylenetetrahydrofolate reductase,glutathione s-transferase and tumor marker and life quality in fluorouracil group were significantly better than those of capecitabine group,the differences were statistically significant（ P〈0. 05）.CONCLUSIONS： The effects of fluorouracil injections in treatment of advanced gastric cancer are significant,which can effectively improve the levels of methylenetetrahydrofolate reductase,glutathione s-transferase and tumor marker,improve patients＇ life quality with few adverse drug reactions.
出处
《中国医院用药评价与分析》
2016年第9期1219-1221,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
