摘要
目的探讨胃腺癌中P53、HER2和Ki-67的表达及其与临床病理特征和侵袭转移的关系。方法收集本科2012年11月~2015年12月病理学确诊为胃腺癌的组织标本142例,采用免疫组化Eli Vision法检测其P53、HER2和Ki-67的表达,并分析其与临床病理特征和侵袭转移的关系。结果 P53、HER2和Ki-67在胃腺癌中表达率分别为70.42%,83.10%和32.39%;P53在肿瘤直径,分化程度,Lauren分型,淋巴结转移和脉管癌栓组中表达差异有统计学意义（P〈0.05）;HER2在不同分化程度,Lauren分型,浸润深度,淋巴结转移和脉管癌栓组表达差异有统计学意义（P〈0.05）;Ki-67在分化程度,Lauren分型,浸润深度和淋巴结转移组中差异有统计学意义（P〈0.05）。P53与Ki-67高表达呈正相关（P〈0.05）;HER2与Ki-67高表达呈正相关（P〈0.05）。结论联合检测P53、HER2和Ki-67在胃腺癌中的表达有利于对胃腺癌患者的预后评估及个体化的分子靶向治疗提供科学依据。
Objective To investigate the expression,clinical significance,invasion and migration of P53,HER2 and Ki-67 in gastric cancers.Methods 142 cases gastric cancers were collected from November 2012 to December 2015 of department of pathology.Immunohistochemistry was used to detect the expression of P53,HER2 and Ki-67 in 142 cases of gastric cancer.The correlation between their expression and pathologic parameters were analyzed by statistics.Results The positive rate of P53,HER2 and Ki-67 in 142 cases of gastric cancer was 70.42%,83.10% and 32.39% respectively.The differences of the expression of P53 in tumor size,different histological grading group,the Lauren classification,lymph node metastasis group and vascular invasion group were statistically significant（P〈0.05）;the expression of HER2 was statistically associated with different histological grading group,the Lauren classification, different depth of invasion,lymph node metastasis group and vascular invasion group（P〈0.05）;the expression of Ki-67 was statistically associated with different histological grading group,the Lauren classification,different depth of invasion,lymph node metastasis group（P〈0.05）.The expression of P53 was positively correlated with Ki-67（P〈0.05）,and so did HER2（P〈0.05）.Conclusion Combined detection of P53,HER2 and Ki-67 has very important significance in judging prognosis and guiding clinical treatment of gastric cancer.
出处
《中国当代医药》
2016年第27期153-155,共3页
China Modern Medicine
