摘要
目的:研究加味柴胡疏肝散对慢性乙型肝炎的治疗效果。方法:纳入2014年1月—12月该院收治的慢性乙型肝炎患者80例,随机均分为两组:对照组仅予恩替卡韦行常规治疗;观察组在对照组基础上联用加味柴胡疏肝散。持续治疗6个月,统计治疗应答率、治疗前后肝功能变化情况、HBV-DNA转阴率、用药期间不良反应情况。结果:观察组治疗应答率明显高于对照组(P<0.05);两组治疗前肝功能指标及HBV-DNA无明显差异,治疗后所有患者肝功能指标及HBV-DNA水平均明显下降,与治疗前相比,差异有显著性意义(P<0.05),且观察组谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)均明显低于对照组、HBV-DNA转阴率明显高于对照组,组间差异有统计学意义(P<0.05);观察组不良反应总发生率均明显低于对照组,组间差异有统计学意义(P<0.05)。结论:加味柴胡疏肝散辅助治疗慢性乙型肝炎,有助于提升疗效、增强肝功能、提升HBV-DNA转阴率、减少治疗不良反应,值得推广。
Objective： To study the modified Chaihu Shugan San（ CHSGS） treatment of chronic hepatitis B treatment effect and guide the clinical treatment of diseases. Methods： A total of 80 patients with chronic hepatitis B from January 2014 to December in our hospital were randomly divided into two groups. The control group only received entecavir for routine treatment and the observation group added the modified CHSGS based on the routine treatment. For 6 months,the statistical treatment response rate,liver function changes before and after treatment,HBV-DNA negative rate and drug adverse reactions were compared. Results： The observation group＇s response rate was significantly higher than that of the control group（ P〈0. 05）. The liver function index and HBV-DNA had no significant difference between the two groups before treatment and after treatment all patients＇ liver function and HBV-DNA level were significantly decreased. Compared with those before treatment,there were significant differences（ P〈0. 05） and the observation group＇s AST,ALT and TBIL were significantly lower than those of the control group. HBV-DNA negative rate was significantly higher than the control group＇s and there was significant difference between the groups（ P〈0. 05）. The total incidence of adverse reactions in the observation group was significantly lower than that of the control group and there was significant difference between the groups（ P〈0. 05）. Conclusion： Modified CHSGS in adjuvant therapy of chronic hepatitis B can help to improve the curative effect,enhance liver function,enhance the conversion rate of HBV-DNA and reduce the adverse reactions,worthy of promotion.
出处
《辽宁中医杂志》
CAS
北大核心
2016年第10期2144-2146,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
柴胡疏肝散
恩替卡韦
中西医结合
慢性乙型肝炎
Chaihu Shugan San
entecavir
combination of TCM and Western medicine
chronic hepatitis B
