摘要
Caspase-8作为细胞死亡信号诱导复合体中不可或缺的一员而一直备受关注,是细胞凋亡信号因子中研究的热门。然而,最近研究指出Caspase-8除了作为细胞凋亡信号中的一员外,还有很多非凋亡活性,比如促进细胞迁移、粘附、增殖分化等,甚至还有研究指出其与细胞炎症及免疫有关。本综述首先针对Caspase-8对细胞迁移信号通路中的影响做出了总结及分析,主要包括:Src对Caspase-8磷酸化的过程,Caspase-8对Rac1、Rab5及Calpain的影响。其次,本文还探讨了Caspase-8在其他信号通路中的非凋亡作用,为以Caspase-8为靶点抑制肿瘤扩散药物的研究提供新的思路。
As the super star in cell death-inducing signaling complex and cell apoptosis signaling factors, Caspase-8 has always been concerned for the research hotpoint. However, the recent researches have reported that Caspase-8 has a lot of non-apoptosis functions. Actually many researches have shown that except as the member of cell apoptosis factors, Caspase-8 can also promote cell migration, adhesion, proliferation and differentiation, and even has some relationship with cell immune and inflammation. Firstly, this review has summarized the functions of Caspase-8 in cell migration signaling, including the process that Caspase-8 is phosphorylated by Src and the influence that Caspase-8 has on Rac, Rab5 and Calpain. Secondly, the review has made a conclusion of functions for Caspase-8 in other cell-signaling pathway, in order to provide a new way for the medicine study of Caspase-8 as a target to inhibit tumor proliferation.
出处
《生命的化学》
CAS
CSCD
2016年第5期704-709,共6页
Chemistry of Life
基金
国家自然科学基金项目(81260351
81360162)
