摘要
目的探讨文拉法辛与帕罗西汀治疗周围性眩晕患者焦虑抑郁的临床疗效。方法从周围性眩晕患者中筛选出合并焦虑抑郁患者180例,随机分为2组,各90例,采用眩晕障碍量表(dizziness handicap inventory,DHI)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)及汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)对患者进行测评,分别给予文拉法辛及帕罗西汀药物治疗,并于服药后2、4、6周再次进行上述评定,根据治疗前后的减分率评价两种药物的临床疗效。结果 2周时文拉法辛组HAMA评分低于帕罗西汀组,2组比较有统计学差异(P<0.05);4周时文拉法辛组HAMD、HAMA评分均低于帕罗西汀组,2组比较有统计学差异(P<0.05);6周后文拉法辛组抗焦虑、抑郁总有效率分别为83.33%及77.78%,帕罗西汀组抗焦虑、抑郁总有效率分别为76.67%及74.45%,两组比较无统计学差异(P>0.05)。2组的DHI评分较治疗前均有明显减低,差异有统计学意义(P<0.05),其中P指数评分文拉法辛组低于帕罗西汀组,比较有统计学差异(P<0.05)。结论文拉法辛与帕罗西汀抗焦虑抑郁的疗效类似,但起效更快,患者依从性更好。二者对周围性眩晕患者的躯体化症状及情绪、功能障碍均有明显改善,其中文拉法辛对减轻躯体症状的疗效更好。
OBJECTIVE To study the efficacyof venlafaxine vs. paroxetine in treatment of peripheral vertigo patients with anxiety and depression. METHODS 180 peripheral vertigo patients with anxiety and depressionwere randomly divided into venlafaxine group（90cases） and paroxetine group（90cases）, and were treated respectively for 6 weeks. The patients were assessed by Dizziness Handicap Inventory（DHI）, Hamilton Depression Scale24（HAMD） and Hamilton Anxiety Scale（HAMA） before and after the treatment at the 2nd, 4th and 6th week respectively. The clinical efficacy of the two drugs was evaluated according to the reduction rate before and after the treatment. RESULTS Atthe 2ndweek, the scores of HAMA in venlafaxine group was lower than paroxetine groupstatistically（P〈0.05）. At the 4th week, both the HMAM and HAMD in venlafaxine group were lower than paroxetine groupstatistically（P〈0.05）. After 6 weeks, The total effective rate of anxiety and depression were 83.33% and 77.78% in venlafaxine group, while 76.67%and 74.45% in paroxetine group. But there was no statistical difference（P＆gt;0.05）. The scores of DHI were decreased in both groups（P〈0.05）, and index p in venlafaxine group was lower than paroxetine group（P〈0.05）. CONCLUSION Both of them can reduce the physical symptoms and dysfunction, are effective on anxiety and depression, but venlafaxine is faster to take effect than paroxetine, and has a better patient compliance.
作者
戴静
孙勍
邓福栋
单希征
DAI Jing SUN Qing DENG Fudong SHAN Xizheng(Department of Otolaryngology Head and Neck Surgery, the General Hospital of Chineses People＇s Armed Police Force, Beijing, 100039, China Department of Psychiatric, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China)
出处
《中国耳鼻咽喉头颈外科》
CSCD
2016年第10期590-593,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
帕罗西汀
焦虑
抑郁
眩晕
文拉法辛
Paroxetine
Anxiety
Depression
Vertigo
venlafaxine
