摘要
目的:探究宽心合剂对颈动脉狭窄支架植入术后脑卒中影响研究。方法:108例颈动脉狭窄患者,根据患者的意愿,分成试验组和对照组,每组54例。对照组按CAS术后常规氯吡格雷与阿司匹林联用抗血小板方案,实验组在对照组的基础上联合使用宽心合剂进行治疗。于治疗后的1、3、6、12月,对两组患者的NIHSS评分、颈动脉TIA和新发脑梗死的发生率进行统计和比较;治疗后的6月和12月,对两组患者的血浆同型半胱氨酸水平(Plasma homocysteine levels,Hcy)进行对照比较;于治疗后的12月,对照比较两组患者的颈动脉狭窄处颈动脉彩超各参数的变化。结果:实验组患者在治疗后的1、3、6、12月NIHSS评分显著的低于对照组的患者(P<0.05);实验组患者在治疗后发生缺血性脑卒中、颈动脉TIA和新发脑梗死的发生率明显低于对照组患者(P<0.05);两组患者在治疗后的6月和12月Hcy均无明显差异(P>0.05);两组患者在治疗后的12月颈动脉狭窄处多普勒相关参数均无明显差异(P>0.05);实验组患者术后的不良反应发生率显著低于对照组(P<0.05)。结论:宽心合剂对颈动脉狭窄支架植入术,具有安全可靠的临床治疗效果,同时还可预防患者脑卒中的发生。
Objective：To explore the influence of Kuanxin Heji on carotid artery stenting of cerebral apoplexy. Method： A total of 108 patients in our hospital from January 2014 to January 2015 were as the research object of carotid artery ste- nosis. In accordance to the wishes of patients, the patients were randomly divided into experimental group and control group ,54 cases in each group. The control group accorded to CAS postoperative conventional clopidogrel and aspirin com- bined with antiplatelet therapy. The experimental group was given Kuanxin treatment on the basis of the control group. After treatment for one, three, six and twelve months, the two groups＇ NIHSS score, carotid TIA and the incidence of new cerebral infarction were statistically and compared. After treatment of six and twelve months, the levels of cysteine in the two groups were compared. After treatment of twelve months, the color Doppler ultrasound parameterschanges of carotid artery stenosis in the two groups were compared. Results ： one, three, six and twelve months after treatment, the NIHSS scores of patients in the experimental group were significantly lower than those in the control group （ P 〈 0. 05 ）. After treatment, the incidence of ischemic stroke, carotid TIA and the new cerebral infarction of the patients in the experimental group were significantly lower than those in the control group （ P 〈 0. 05 ）. There were no significant differences in Hcy levels between the two groups at six and twelve months after treatment（ P 〉 0.05）. There were no significant differences in the parameters of Doppler in the two groups at twelve months after treatment （ P 〉 0. 05 ）. The incidence of adverse re- actions in the experimental group was significantly lower than that in the control group （P 〈 0.05 ）. Conclusion ： Kuanxin Heji on carotid artery stenting is safe＇and has reliable clinical curative effect. It also can prevent stroke.
出处
《中华中医药学刊》
CAS
北大核心
2016年第11期2691-2693,共3页
Chinese Archives of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(2014270)
关键词
宽心合剂
颈动脉狭窄
支架
脑卒中
Kuanxin Heji
carotid artery stenosis
stent
stroke
