摘要
目的评价盐酸羟考酮对全麻病人苏醒质量的影响。方法妇科肿瘤切除手术患者72例,年龄35~65岁,ASAⅠ或Ⅱ级,随机分为三组：羟考酮组（A组）、芬太尼组（B组）和对照组（C组）,每组24例。所有病人手术结束前10min三组分别静脉注射盐酸羟考酮1.5mg/kg、芬太尼1μg/kg、生理盐水5m L。记录患者自主呼吸恢复时间、苏醒时间、拔除气管导管时间;拔除气管导管前后1、5、10min的MAP、SPO2、Ramsay评分及不良反应;拔管后30min、1h和2h的VRS痛觉评分。结果 B组病人自主呼吸恢复时间、苏醒时间和拔管时间明显延长（t=9.58,P〈0.05）;B、C组病人在拔管后各时点比A组HR增快,MAP升高,且C组尤为显著（t=6.35/11.46,P〈0.05）。A、B组病人在拔管前后的各时点的Ramsay评分明显高于C组病人（t=2.13,P〈0.05）。B、C组较A组病人在拔管后的各时点VRS评分明显升高,差异显著（t=7.46,P〈0.05）,尤以C组表现最为明显（t=11.62,P〈0.05）。A组不良反应发生率明显低于B组和C组（χ~2=6.27,P〈0.05）。结论预注盐酸羟考酮全身麻醉病人苏醒迅速,血流动力学稳定,镇静镇痛满意,不良反应少,可以提高患者苏醒质量。
Objective To evaluate the effect of oxyeodone hydrochloride on the recovery quality of general anesthesia patients. Method Seventy-two patients undergoing gynecological tumor resection, aged 35-65 years old, ASA grade I or II, were randomly divided into groups ： oxycodone hydroehloride group （ group A）, fentanyl group （ group B）, and control group （ group C） with 24 cases in each group At lOmin before the end of surgery, patients in group A, B and C were intravenously injected with oxycodone （1.5mg/kg） , and fentan （lμg/kg） and 5ml saline, respectively. Spontaneous breathing recovery time, awaking time and extubation time of all patients wer recorded. MAP, SPO2 and Ramsay scores at 1, 5, I0 mins before and after extubation as well as adverse reactions of all patients wer monitored. At 30rain, lh and 2h after extubation, VRS pain scores of all patients was recorded. Results Spontaneous breathing recover time, awaking time and extubatian time in group B prolonged significantly （ t = 9.58, P 〈 0.05 ）. At every time point after extubation, th HR and MAP in group B and C elevated obviously than in group A, and they were more obvious in group C （ t value was 6.35 and 11.46 both P 〈 0.05 ）. At every time point before and after extubation, the Ramsay scores in group A and B were higher than those in group C （ =2.13, P 〈0.05）. After extubation at every time point the VRS scores in group B and C elevated obviously compared to group A （t = 7.46, P 〈 0.05 ）, especially in group C （ t = 11.62, P 〈 0.05）. The adverse reactions in group A were significantly lower than those i other two groups （X2 = 6.27, P 〈 0.05 ）. Conclusion Oxyeodone hydroehloride intravenous injection for patients undergoing general anesthesia can achieve the advantages of rapid awakening, stable hemodynamies, satisfactory sedation and analgesia, few adverse reaction and improving recovery quality as well.
出处
《中国妇幼健康研究》
2016年第9期1145-1148,共4页
Chinese Journal of Woman and Child Health Research
关键词
盐酸羟考酮
气管插管
全身麻醉
苏醒质量
oxycodone hydrochloride
tracheal intubation
general anesthesia
recovery quality
