摘要
目的探讨血清HE4、NSE、CYFRA21-1水平变化对肺癌的诊断价值。方法采用电化学发光法检测88例肺癌患者和70例肺良性疾病患者及50例健康对照者血清中的HE4、NSE、CYFRA21-1水平。结果肺癌组血清HE4、NSE、CYFRA21-1水平明显高于肺良性疾病组和健康对照组(P<0.05);腺癌、鳞癌、小细胞肺癌分别以HE4、CYFRA21-1、N SE检测敏感性最高(P<0.05);HE4、NSE、CYFRA21-1联合检测较单项检测诊断敏感性显著提高(P<0.05)。结论 HE4、NSE、CYFRA21-1水平变化有助于肺癌的诊断和鉴别诊断,三项肿瘤标志物联合检测优于各项目单独检测。
Objective To investigate the diagnostic value of serum HFA, NSE and CYFRA21-1 levels for lung cancer. Methods The serum HFA, NSE and CYFRA21-1 levels in 88 patients with lung cancer and 70 pa- tients with benign lung disease patients and 50 healthy control was detected by using chemoluminescenee method. Re- suits The serum HFA, NSE and CYFRA21-1 levels in lung cancer were significantly higher than that in benign lung disease and the healthy control group （ P 〈 0. 05 ）. The highest sensitivity of serum tumor markers in adencarcinoma, squamous cell carcinoma and small cell lung cancer was HFA, CYFRA21-1 and NSE respectively. Compared with each single item, the diagnostic sensitivity of the combined detection of HFA, NSE and CYFRA21-1 was greatly im- proved （P 〈 0. 05）. Conclusion The serum HE4, NSE and CYFRA21-1 levels contribute to the diagnosis and dif- ferential diagnosis of lung cancer, and the three combined detection of tumor markers is superior to each project indi- vidually tested.
出处
《临床肺科杂志》
2016年第12期2159-2161,共3页
Journal of Clinical Pulmonary Medicine
