摘要
目的:探讨防风通圣散加减治疗颜面部激素耐药型过敏性皮炎的临床疗效及血清IgE水平影响。方法:将70例患者按随机数字表法对照组和观察组,每组35例。对照组采用西医对症治疗,观察组在对照组治疗基础上联合防风通圣散(防风、川芎、当归、芍药、大黄、薄荷叶、麻黄、连翘、芒硝、石膏、黄芩、桔梗、滑石、甘草、荆芥、白术、栀子)治疗。治疗后测定并记录两组患者嗜酸性粒细胞、IgE水平、炎症指标、生存质量、心理状况,同时比较临床疗效及不良反应状况。结果:对照组有效率为71.43%,观察组有效率为91.43%,差异有统计学意义(P<0.05);与对照组比较,观察组治疗后嗜酸性粒细胞及IgE水平降低,治疗后血清IL-4、IL-13含量降低,血清IL-18及γ-IFN含量升高,治疗后生存质量及心理状况改善程度更好,差异有统计学意义(P<0.05)。结论:防风通圣散加减治疗颜面部激素耐药型过敏性皮炎效果显著,能降低血清IgE水平。
Objective： To discuss the clinical curative effect of Modified Fangfeng Tongsheng San treatment of facial hormone resistant type allergic dermatitis and its effect on serum IgE. Methods： 70 cases of patients were randomly divided to the control group and the observation group,35 cases in each group. The control group was given symptomatic treatment,and the observation group was treated with Fangfeng Tongsheng San based on the control group. After treatment,the levels of eosinophils and IgE,inflammatory markers,quality of life and psychological status of the two groups were measured and recorded,and the clinical efficacy and adverse reactions were compared. Results： The effective rate in control group（ 71. 43%） was lower than that of treatment group（ 91. 43%）,with significant difference（ P〈0. 05）,and compared with the control group,eosinophil eosinophil and IgE levels in the treatment group were lower,serum IL-4 and IL-13 levels were lower,serum IL-18 and IFN content were higher（ P〈0. 05）. After treatment,survival quality and psychological status improvement were better,with statistical significance（ P〈0. 05）. Conclusion： Modified Fangfeng Tongsheng San treatment of facial hormone resistant type allergic dermatitis has significant effect,which can reduce the level of serum IgE.
出处
《中医学报》
CAS
2016年第10期1582-1585,共4页
Acta Chinese Medicine
基金
山东大学齐鲁医院科研基金资助项目(2015QLMS48)
关键词
颜面部激素耐药型过敏性皮炎
防风通圣散
血清IGE
中医药疗法
中西医结合
facial hormone resistant type allergic dermatitis
Fangfeng Tongsheng San
serum IgE
TCM therapy
integrated tradi tional Chinese and western medicine
