摘要
目的:比较桑螵蛸生品、制品的补肾助阳作用,并探究最佳药用部位。方法:将大鼠随机分为正常对照组、模型组、右归丸组及桑螵蛸生品组、盐炒组、蒸品组、生品虫卵组、生品卵壳组、盐炒虫卵组、盐炒卵壳组、蒸品虫卵组、蒸品卵壳组。氢化可的松造成肾阳虚模型,治疗4 w后,通过比较下丘脑一氧化氮(NO)、促甲状腺激素(TSH)、甲状腺指数、三碘甲腺原氨酸(T3)、四碘甲腺原氨酸(T4)、肾上腺指数、肾脏指数、肾上腺素(EPI)、去甲肾上腺素(NE)、17-羟皮质类固醇(17-OH)、皮质醇(CORT)、睾酮(T)、雌二醇(E2)、体质量、饮水量、体温等指标的影响,比较桑螵蛸生品和制品补肾壮阳作用的差异。结果:治疗4 w之后,桑螵蛸各给药组均能提高肾阳虚大鼠的甲状腺指数、肾上腺指数及TSH、T3、T4、EPI、NE、17-OH、CORT、T含量,增加体质量和体温,并能降低NO、E2含量和肾脏指数,减小饮水量,其中盐炒组和盐炒虫卵组效果最为显著。结论:桑螵蛸经炮制后补肾助阳作用增强,盐炒品>蒸品>生品。盐炒品的虫卵是桑螵蛸补肾助阳的主要药用部位,其药效是通过增强下丘脑-垂体-甲状腺轴、肾上腺轴、性腺轴的功能来实现的。
Ojective： To compare the effects of antis egg-case before and after preparing in reproducing kidney-Yang deficiency model rats,and to explore the best medicinal part of antis egg-case. Methods： Divide the rats into nine groups randomly： antis egg-case group,salt fried antis egg-case group,steamed antis egg-case group,eggs from antis egg-case group,eggs from salt fried antis egg-case group,eggs from steamed antis egg-case group,egg shell from antis egg-case group,egg shell from salt fried antis egg-case group,and egg shell from the steamed antis egg-case group. Make kidney-Yang deficient model by giving the rats hydrocortisone. Two weeks later,give the rats treatment for four weeks,compare the effects of antis egg-case by determining the contents of NO,TSH,T3,T4,EPI,NE,17-OH,CORT,T,E2,coefficient of thyroid,body temperature,coefficient of adrenal and kidney,weight and water intake. Results： Antis egg-case before and after preparing increased the contents of T3,T4,EPI,NE and T,increased weight,body temperature,coefficient of thyroid and adrenal,but reduced the contents of NO and E2,the coefficient of kidney and water intake were also decreased. Conclusion：The medicinal materials came from different medicinal parts of antis egg-case before and after preparing can treat the symptoms of kidney-Yang in different degrees. The effects of antis egg-case to treat kidney-Yang deficient has been strengthened after preparing,salt fried antis egg-case and eggs from salt fried antis egg-case played the more important role.
作者
贾坤静
艾雪
贾天柱
鞠成国
JIA Kun-jing AI Xue JIA Tian-zhu JU Cheng-guo(School of Pharmcy, Liaoning University of Traditional Chinese Medicine/Key Laboratory of Processing Theory Analysis of State Admin- istration of Traditional Chinese Medicine/Chinese Materia Medica Processing Engineering Center of Liaoning Province, Dalian 116600, China)
出处
《中药材》
CAS
CSCD
北大核心
2016年第7期1516-1520,共5页
Journal of Chinese Medicinal Materials
基金
国家中医药管理局行业专项(201107007)
关键词
桑螵蛸
补肾助阳
药用部位
炮制
Antis egg-case
Reinforce the kidney-Yang
Different medicinal parts
Preparation
