摘要
目的确立小儿温热口服液(XWOL)的最优提取工艺。方法通过镇痛、抗炎、解热药效学实验初选提取工艺路线,再以挥发油的提取量为指标,单因素考察浸泡时间、提取时间对鱼腥草等药材挥发油提取的影响;以连翘苷、黄芩苷的提取率及总评"归一值"为指标,通过中心复合设计-效应面法优选水提工艺。结果XWOL最佳提取工艺路线为鱼腥草等药材加入10倍量的水,水蒸气蒸馏6 h,收集挥发油及水煎液,药渣与黄芩等药材加入13倍量的水提取2次,每次80 min。结论该提取工艺合理,稳定,可用于工业化大生产。
Objective To optimize the extraction process of Xiaoer Wenre Oral Liquid （XWOL）. Methods Through the analgesic, anti-inflammatory and antipyretic pharmacological experiments, the best extraction process route was primarily optimized, then taking the volatile oil amount as index, single factor test was adopted to investigate the effects of the soaking time and extracting time on extraction process of volatile oil; With contents of phillyrin, baicalin, and overall desirability as comprehensive evaluation indexes, central composite design-response surface method was adopted to predict the water extraction process. Results Adding 10 times water, extracting for 6 h, collecting volatile oil and water extract, then the dregs and other medicines were extracted twice with 13 times water, for 80 min each time. Conclusion The optimized extraction process is reasonable and feasible, and it can be used in a large scale industrial production.
出处
《中草药》
CAS
CSCD
北大核心
2016年第20期3632-3638,共7页
Chinese Traditional and Herbal Drugs
基金
基金项目:重庆市"121"科技支撑示范工程(cstc2016fazktjcsfl0009)
关键词
小儿温热口服液
解热
抗炎
镇痛
连翘苷
黄芩苷
挥发油
中心复合设计-效应面法
Xiaoer Wenre Oral Liquid
antipyretic
anti-inflammatory
analgesia
phillyrin
baicalin
volatile oil
central compositedesign-response surface method
