摘要
目的通过检测尿液前列腺小体外泄蛋白（PSEP）来评估其作为慢性前列腺炎诊断标记物的临床价值。方法收集NIH-Ⅲb型前列腺炎患者107例和健康对照96例的尿液标本，采用ELISA方法对收集的尿液样本进行PSEP的检测。比较前列腺炎组与对照组之间尿液PSEP水平的差异。采用受试者工作特征（ROC）曲线计算灵敏度、特异度并计算最大约登指数，得出最佳诊断界值。结果两组尿液PSEP数据均呈非正态分布，前列腺炎组中位PSEP为1.133（0.371~3.580）ng/ mL，显著高于对照组0.193（0~0.734）ng/ mL（P＜0.01）。对PSEP检测结果进行ROC曲线拟合，曲线下面积为0.755，诊断界值为1.237 ng/mL，敏感性为51.4%，特异性为88.5%。结论尿液PSEP作为NIH-Ⅲb型前列腺炎的辅助诊断指标，其诊断效能中等，但具有较高的可操作性和较好的临床应用价值。
ObjectiveUrine prostatic exosomal protein （PSEP） was detected to evaluate its clinical potential as a diagnostic marker of chronic prostatitis （CP）. MethodsA total of 107 cases of NIH-IIIb prostatitis and 96 healthy controls were enrolled. Urine samples were collected for ELISA testing. PSEP levels were compared between the two groups. A ROC curve was drawn to calculate the sensitivity, specificity and optimum Youden index, so as to figure out the cut-off value of PSEP. ResultsThe median PSEP of the prostatitis group was 1.133（0.371-3.580） ng/mL, which was higher than that of the control group／[0.193 （0-0.734）ng/mL,P〈0.01]. The area under the ROC curve was 0.755. The diagnostic cutoff value was 1.237 ng/mL, the sensitivity was 51.4%, and the specificity was 88.5%.ConclusionUrine PSEP as a diagnostic marker of NIH- IIIb prostatitis, shows a medium ability in the diagnosis of CP, but it has good operability and clinical value.
出处
《现代泌尿外科杂志》
CAS
2016年第11期861-863,共3页
Journal of Modern Urology
