摘要
糖尿病认知功能障碍(cognitive impairment in diabetes,CID)是糖尿病的慢性并发症之一,临床表现主要为轻、中度认知功能障碍,学习和记忆能力下降,其发病机理尚不明确。NF-κB是原始的信号激活因子,可导致细胞机能紊乱和损伤的其他通路激活。在高糖及氧化应激等环境下,NF-κB表达增强导致NOS、MMP-9、TNF-α等因子的表达也发生改变,继而引起一系列的病理变化,导致海马神经元细胞凋亡。文中以NF-κB为切入点,探讨NF-κB及其相关因子NOS、MMP-9、TNF-α与CID的关系,为进一步深入研究CID打下基础。
Cognitive impairment in diabetes（CID） is one of the complications of diabetes.The features of mild or moderate cognitive disorder and the decread abilities in memory and studying are the main symptoms of CID.But it＇ s mechanism is still unknown.NF-κB is the original signal activator,it can activate other signal pathway of cell dysfunction.With the influence of hyperglycemia and oxidative stress,the expression of NF-κB is enhanced,that leads to the changes of the expression of NOS,MMP-9,TNF-α,then,these changes lead to the apoptosis of hippocampus neuron cell.This review focuses on NF-κB in order to provide evidences in studying CID by reviewing the relationship between NF-κB and it＇s relative factors of NOS,MMP-9,TNF-α and CID.
出处
《医学研究生学报》
CAS
北大核心
2016年第7期754-758,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81200840
81360176
81360128)
云南省科技计划项目(2013FZ055)
云南省中青年学术技术带头人后备人才培养计划(2013HB078)
云南省教育厅科学研究基金(2013Z105)
