摘要
调节性T细胞(regulatory T cells,Treg)是一类能够抑制自身免疫反应、特异性表达Foxp3、分泌IL-10和TGF-β等细胞内因子的CD4+T淋巴细胞亚群。其作用机制是通过调控性抑制效应性T细胞、肥大细胞、树状细胞及B细胞的活性和免疫反应,在预防自身免疫性疾病及肿瘤免疫和抑制耐受方面发挥关键作用。当其功能或数量发生异常变化时,会导致多种自身免疫性疾病的发生。同时,调节性T细胞免疫疗法有可能成为治疗自身免疫性疾病的新途径。本文对CD4+C25+Foxp3+调节性T细胞在自身免疫性疾病中的研究进展进行综述。
Regulatory T cells（Treg） usually are defined as several subsets of CD4＋cells, which share somecommon features including expression of Foxp3（except for Tr1 cells） and secretion of inhibitory cytokine IL-10 and/or TGF-β. Tregs play crucial role in negatively controlling immune activity by their actions on suppression ofeffector T cells and inhibiting activation of mast cells, dentritic cells and B cells. In addition to transplant rejection,infection and cancer, it is noticeable that Tregs likely contribute to some autoimmune disorders such as type Idiabetes mellitus, systemic lupus erythematosus and rheumatoid arthritis et al. Modulation of functions of Tregs mayprovide a novel strategy to prevent and treat autoimmune diseases.
作者
史国星
曾强
窦剑
李伟
SHI Guoxing ZENG Qiang LI Wei DOU Jian(Department of Hepatobiliary Surgery, Third Hospital of Hebei Medical University, Shifiazhuang 050051, China Research Center, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China)
出处
《免疫学杂志》
CAS
CSCD
北大核心
2016年第12期1092-1095,共4页
Immunological Journal
