摘要
目的探讨利培酮联合喹硫平治疗阿尔茨海默病(老年痴呆)患者精神行为症状(BPSD)的疗效及安全性。方法将该院老年科2013年1月至2015年12月收治的老年痴呆BPSD患者90例采用完全随机法随机分为联合组、利培酮组和喹硫平组,每组30例。联合组给予利培酮联合喹硫平治疗,利培酮组给予利培酮治疗,喹硫平组给予喹硫平治疗。于治疗前及治疗2、4、8周后分别采用痴呆病理行为评定量表(BEHAVE-AD)判定疗效,不良反应量表评价不良反应发生情况。结果三组患者治疗2、4、8周后BEHAVE-AD评分均明显低于治疗前,差异均有统计学意义(P<0.05);联合组疗效与利培酮组相当,差异无统计学意义(P>0.05),但明显优于喹硫平组,差异有统计学意义(χ2=15.39,P<0.01)。利培酮组不良反应发生率明显高于联合组、喹硫平组,差异均有统计学意义(P<0.05)。结论利培酮联合喹硫平治疗老年痴呆BPSD具有较好疗效,不良反应小,更适于老年痴呆患者的治疗。
Objective To investigate the efficacy and safety of risperidone combined with quetiapine in the treatment behavioral and psychiatric symptoms of dementia （BPSD）. Methods Ninety cases of BPSD in the geriatric department of our hospital from January 2013 to December 2015 were randomly divided into the combination group , risperidone group and quetiap-ine group according to the completely random method ,30 cases in each group. The combination group was given risperidone com-bined with quetiapine, the risperidone group was given the risperidone therapy and quetiapine group received the quetiapine therapy. The treatment effects were evaluated by using the BEHAVE-AD before treatment and after 2-,4-,8-week treatment. The side effects scale（TESS） was used to evaluate the adverse reactions occurrence situation. Results The AD-BEHAVE scores after 2-,4-,8-week treatment in 3 groups were significantly lower than those before treatment ,the difference was statistically significant （P〈0.05）;the effect in the combination group was similar to that in the risperidone group,the difference had no statistical signifi-cance（P〉0.05）,but the effect in the combination group was significantly superior to that in the quetiapine group（χ^2=15.39,P〈0.05）. The occurrence rate of adverse reactions in the risperidone group was significantly higher than that in the combination group and quetiapine group,and the difference was statistically significant（P〈0.05）. Conclusion Risperidone combined with quetiapine in the treatment of elderly BPSD has good curative effect,small adverse reactions,which is more suitable for the patients with senile dementia.
出处
《现代医药卫生》
2016年第22期3446-3447,3450,共3页
Journal of Modern Medicine & Health
关键词
痴呆
行为症状/药物疗法
利哌立酮
喹硫平
Dementia
Behavioral symptoms/drug therapy
Risperidone
Quetiapine
