摘要
目的探讨组织选择性雌激素对围绝经期女性冠心病预防效果。方法将该院门诊以胸闷、心悸及月经不调就诊,并最终经多次心电图检测确诊的非冠心病患者72例随机分成为观察组和对照组各36例。观察组患者均给予组织选择性雌激素替勃龙口服治疗,对照组患者均给予维生素C、E口服治疗。结果观察组患者的冠心病发病率明显低于对照组患者(P<0.05);性激素水平、血脂指标和血管性能指标的改善均明显优于对照组患者(P<0.05)。结论组织选择性雌激素可以降低围绝经期女性冠心病的发病率,改善患者的血液相关指标,值得推广使用。
Objective To explore the effect of tissue selective estrogen on prevention of coronary heart disease （CHD） in perimenopausal women. Methods Seventy-two perimenopausal women went to the hospital because of choking sensation in chest, palpitate, and irregular menstruation, then they were diagnosed as CHD definitely by electrocardiogram, all the perimenopausal women were randomly divided into control group and observation group, 36 perimenopausal women in each group. The patients in observation group were treated by oral administration of tissue selective estrogen （tibolone）, while the patients in control group were treated by vitamin C and vitamin E. Results The incidence rate of CHD in observation group was statistically significantly lower than that in control group （P〈0. 05） ; the improvements of sex hormones levels, blood lipid indexes, and blood vessel performance indexes in observation group were statistically significantly better than those in control group （P〈0. 05） . Conclusion Tissue selective estrogen can reduce the incidence rate of CHD and improve blood-related indexes in perimenopausal women, which is worthy of promotion and application.
出处
《中国妇幼保健》
CAS
2016年第23期5088-5090,共3页
Maternal and Child Health Care of China
关键词
冠心病
围绝经期
组织选择性
雌激素
预防
Coronary heart disease
Perimenopausal period
Tissue selective
Estrogen
Prevention
