摘要
目的：探讨高原缺氧与2型糖尿病患者服用二甲双胍导致乳酸中毒的相关性。方法：选取四川省阿坝州人民医院收治的生活在高原地区（海拔3OOO～4000m）且伴有2型糖尿病患者34例作为高原组，同时选取平原地区（海拔高度％500m）的2型糖尿病患者40例作为对照组（平原组），观察两组患者乳酸中毒的发生率、空腹血糖、餐后2h血糖、糖化血红蛋白差异，并采用Pearson相关性检验对其相关性进行分析。结果：两组患者治疗24周后血糖水平降低幅度相似，组间比较差异无统计学意义（均P〉0．05）；高原组患者乳酸中毒的发生率为17．65％，显著高于平原组的2．50％，两组乳酸中毒发生率相比，差异有统计学意义（P〈0．05）；经Pearson相关性分析，高原缺氧与2型糖尿病患者服用二甲双胍与乳酸中毒呈正相关关系（r=0．369，P〈0．05）。结论：处于高原缺氧状态下的2型糖尿病患者服用二甲双胍发生乳酸中毒的概率高于平原地区2型糖尿病患者，且高原缺氧与2型糖尿病患者服用二甲双胍与乳酸中毒呈正相关关系，应引起临床的重视与关注。
Objective： To explore the correlation between high altitude hypoxia and metformin-induced lactic acidosis in patients with type 2 diabetes Methods： 34 cases mellitus living in of patients with type 2 plateau area （ altitude mellitus. diabetes 3, 000-4,000 m） were selected as the plateau group, and 34 patients living in plain area （altitude G500 m） were selected as the control group. Both groups of patients were treated with metformin. The incidence of lactic acidosis, fasting blood glucose, 2 h postprandial blood glucose and glycosylated hemoglobin were compared between the two groups. Results： After 24 weeks of treatment, blood glucose level was decreased in both groups, and the difference was not significant （ P 〉0.05）. The incidence of lactic acidosis was 17.65% in the plateau group, which was significantly higher than that in the control group（2.50%） （ P 〈0.05）. Hy- poxia was positively correlated with metformin-induced lactic acidosis in patients with type 2 diabetes （ r = 0. 369, P 〈0.05）. Conclusion： The patients with type 2 diabetes who living in plateau area and taking met- formin were more prone to suffering lactic acidosis than those who living in plain area, and there was a pos- itive correlation between high altitude hypoxia and metformin-induced lactic acidosis in patients with type 2 diabetes.
出处
《广西医科大学学报》
CAS
2016年第6期1009-1011,共3页
Journal of Guangxi Medical University
关键词
2型糖尿病
二甲双胍
高原缺氧
乳酸中毒
type 2 diabetes
rnetformin
high altitude hypoxia
lactic acidosis
