摘要
目的观察通心络胶囊治疗老年认知功能障碍的疗效及其对脑血流量、一氧化氮、内皮素的影响。方法选择2012年1月—2016年1月河北以岭医院脑病科诊治的老年认知功能障碍患者120例作为研究对象,按数字随机表法分为2组,治疗组60例给予通心络胶囊治疗,对照组60例给予银杏叶片治疗,时间均为3个月。采用精神状态简易速检表（MMSE）及日常生活自理量表（ADL）观察治疗前后2组患者临床疗效,检测脑血流量及内皮素及一氧化氮的变化。结果治疗组总有效率为90.0%,高于对照组的70.0%（χ~2=7.500,P=0.006）。治疗组MMSE和ADL评分优于对照组（MMSE评分：t=-3.005,P=0.003;ADL评分：t=-5.476,P=0.000）,脑血流量改善治疗组优于对照组（t=3.400,P=0.001）,甲襞微循环改善治疗组优于对照组（管攀形态积分：t=3.775,P=0.000;血流状态积分：t=3.534,P=0.001;攀周积分：t=2.810,P=0.006;总积分比较t=3.090,P=0.003）,内皮素、一氧化氮改善治疗组优于对照组（内皮素：t=1.159,P=0.132;一氧化氮：t=-2.442,P=0.016）。结论通心络治疗老年认知功能障碍疗效优于银杏叶片,尤其在脑循环保护上显现出其优势,这可能是其治疗老年认知功能障碍的作用机制之一。
Objective To observe the therapeutic effect of Tongxinluo capsule on senile cognitive dysfunction and its effect on cerebral blood flow,nitric oxide and endothelin.Methods From January 2012 to January 2016,120 cases of elderly patients with cognitive impairment in Hebei Yiling hospital diagnosis and treatment of encephalopathy were enrolled as the research object,they were randomly divided into treatment group with 60 cases,according to TCM syndrome,they were given Tongxinluo capsule,60 cases in control group were given Ginkgo Biloba Leaves Extract Tablets,treatment duration were 3months.Clinical efficacy,cerebral blood flow and changes of endothelin and nitric oxide were observed in 2 groups of patients before and after treatment using simple mental state simple speed test（MMSE） and daily life self care scale（ADL）.Results The overall efficacy in treatment group was higher than that of control group（90.0%vs.70.0%,χ~2=7.500,P=0.006）,improving MMSE and ADL score of the Tongxinluo group were better than that of Ginkgo biloba group（MMSE：t=-3.005,P=0.003;ADL：t=-5.476,P=0.000）,cerebral blood flow improvement showed significant difference between the 2goups（t=3.400,P=0.001）,improvement of the nailfold microcirculation in Tongxinluo group was better than that of Ginkgo biloba group,there was significant difference（t=3.775,P=0.000;t=3.534,P=0.001;t=2.810,P=0.006;t=3.090,P=0.003）,nitric oxide improvement of Tongxinluo group was better than that of Ginkgo biloba group（t=1.159,P=0.132;t=-2.442,P=0.016）.Conclusion The therapeutic effect of Tongxinluo in the treatment of senile cognitive dysfunction is better than that of Ginkgo biloba,especially in the protection of cerebral circulation,which may be one of the ways to treat cognitive dysfunction in the elderly.
出处
《疑难病杂志》
CAS
2016年第12期1275-1278,共4页
Chinese Journal of Difficult and Complicated Cases
基金
河北省中医药管理局资助项目(2011095)
