摘要
目的对某院抗肿瘤靶向药物阿帕替尼临床应用情况进行回顾性调查分析并评价。方法调取某院2015年4月-2016年3月使用阿帕替尼的病例，评价其用药合理性及安全性。结果2015年4月～2016年3月使用阿帕替尼的患者84例，符合药品说明书适应证有15例（占15．48％），不良反应主要为消化系统、高血压、皮肤毒性反应及骨髓抑制。结论阿帕替尼在临床应用中存在超说明书适应证用药、用法用量不适宜，临床上应高度重视该药的合理使用，临床药师应以此为工作切入点，提高药物治疗的安全性和有效性，促进临床合理用药。
OBJECTIVE To evaluate retrospectively the clinical application of apatinib in a hospital. METHODS The medical records including apatinib were collected during April 2015 to March 2016. Then, the rationality and safety of drug use were evaluated. RESULTS The 84 patients used apatinib during this time, while 15.48% （ 15 patients） conformed to the approved indications. The major adverse reactions were gastrointestinal disorders, hypertension, skin disorders and myelosuppression. CONCLUSION Irration- al use of apatinib such as off-label use, inadequate usage and dosage exists in clinic. Clinicians should pay close attention to the ration- ality of apatinib, and clinical pharmacists can improve the safety and effectiveness of therapeutic drugs by taking this as the break- through point.
作者
尹月
邱新野
鞠蕾
张婉璐
付桂英
YIN Yue QIU Xin-ye JV Lei ZHANG Wan-lu FU Gui-ying(Department of Pharmacy, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, China Department of Pharmacy, Bering Youan Hospital, Capital Medical Universty , Beijing 100069, China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2016年第24期2139-2142,共4页
Chinese Pharmaceutical Journal
关键词
阿帕替尼
靶向药物
合理用药
临床药师
apatinib
targeted therapy
rational application
clinical pharmacist
