摘要
目的探讨抗结核病药物在60岁以上老年肺结核治疗中的不良反应及影响因素。方法回顾性分析我院2012年10月至2015年10月间收治的602例60岁以上老年肺结核患者的临床资料。结果本组602例老年肺结核患者中,出现药物不良反应患者178例,主要类型为肝功能损害、胃肠道反应、神经系统损害。单因素分析显示,不同年龄、BMI、治疗类型及肝病史的患者,其不良反应发生率差异有统计学意义(P<0.05);多因素结果显示,年龄、BMI及肝病史是影响老年肺结核抗结核病药物治疗不良反应发生的独立危险因素。结论高龄、BMI过高或过低、存在肝病史是影响老年肺结核抗结核病药物治疗不良反应的独立危险因素,应当加强问询与调查,针对高不良反应发生风险的患者加强辅助治疗干预,以减少不良反应的发生。
Objective To analyze the adverse reactions and influencing factors of anti-tuberculosis drugs in the treatment of pulmonary tuberculosis in elderly patients aged over 60 years. Methods The clinical data of 602 cases of over 60-year-old patients with pulmonary tuberculosis in our hospital from October 2012 to October 2015 were retrospectively analyzed. Results There were 178 patients with adverse drug reaction among 602 cases. The main types were liver damage, gastrointestinal reaction and nervous system damage. Univariate analysis showed that age, BMI, type of treatment and history of liver disease were related to the incidence of adverse reactions （P 〈0.05）; Multi-factor results showed that age, BMI and liver disease history were the independent risk factors for adverse drug reactions of anti-tuberculosis drugs in elderly tuberculosis patients. Conclusions Age, extremely high or low BMI and history of liver disease are the independent risk factors of adverse reactions of anti-tuberculosis drugs for elderly tuberculosis. We should strengthen the inquiry and investigation for patients with high risk of adverse reactions, and take adjuvant therapy intervention to reduce adverse reaction.
作者
王时桦
WANG Shihua(Department of Tuberculosis Control, the Chronic Disease Prevention Station of Chenghai District, Shantou 515800, China)
出处
《临床医学工程》
2016年第12期1715-1716,共2页
Clinical Medicine & Engineering
关键词
抗结核病药物
老年肺结核
不良反应
影响因素
Anti-tuberculosis drugs
Elderly tuberculosis
Adverse reactions
Influencing factors
