摘要
目的探讨微生态调节剂与谷氨酰胺联合应用对老年患者肠内营养相关性腹泻的预防效果.方法选取2014-02/2016-03在北京市海淀医院接受肠内营养治疗老年患者82例为研究对象,采用随机数字表法分为治疗组与对照组,对照组患者给予鼻饲肠内营养混悬液和微生态制剂,治疗组在对照组的基础上加用谷氨酰胺,对比两组患者腹泻发生率、鼻饲前及鼻饲第8天体液免疫功能指标及肠内营养液达到目标供给量时间.结果与对照组对比,治疗组患者腹泻率显著降低,差异有统计学意义(P<0.05);鼻饲前及鼻饲后两组患者的免疫球蛋白G及免疫球蛋白M水平对比均为显著差异,差异无统计学意义(P>0.05),与鼻饲前对比,治疗组患者的免疫球蛋白A(immunoglobulin A,IgA)水平显著升高,且鼻饲后显著高于对照组患者的IgA水平,差异有统计学意义(P<0.05);与对照组对比,治疗组患者肠内营养达到目标供给量所需时间显著缩短,差异有统计学意义(P<0.05).结论微生态调节剂与谷氨酰胺联合应用有助于降低老年患者肠内营养相关性腹泻的发生率,改善老年患者免疫功能,值得临床推广应用.
AIM To evaluate the effect of combined application of micro-ecological regulator and glutamine in the prevention of diarrhea in elderly patients.METHODS From February 2014 to March 2016,82 elderly patients who received enteral nutrition therapy at our hospital were randomly divided into a treatment group and a control group.Both groups were treated by nasogastric administration of enteral nutrition suspension and probiotics,and the treatment group was additionally given glutamine.The incidence of diarrhea,humoral immune parameters before nasal administration and at 8 d after nasal administration,and the time required for enteral nutrition suspension to reach the desired amount were compared between the two groups.RESULTS Compared to the control group,the incidence of diarrhea decreased significantly in the treatment group（P〈0.05）.IgG and IgM levels did not differ significantly between before and after nasal administration in both groups（P〉0.05）;however,IgA levels were significantly increased after nasal feeding in the treatment group,and IgA levels after treatment were significantly higher in the treatment group than in the control group（P〈0.05）.Compared with the control group,the time required for enteral nutrition suspension to reach the desired amount was significantly shorter in the treatment group than in the control group（P〈0.05）.CONCLUSION The combination of micro-ecological regulator and glutamine is helpful to reduce the incidence of intestinal nutrition related diarrhea and improve the immune function in elderly patients.
出处
《世界华人消化杂志》
CAS
2016年第34期4604-4607,共4页
World Chinese Journal of Digestology
关键词
微生态调节剂
谷氨酰胺
肠内营养
腹泻
Micro-ecological regulator
Glutamine
Enteral nutrition
Diarrhea
