摘要
目的:对运脾颗粒成型工艺、临界相对湿度(CRH)以及质量标准的含测提取方法进行考察研究。方法:以颗粒的成型性、休止角、溶化性以及吸湿性作为测评指标,单因素试验法考察乙醇不同浓度、不同用量对其成型性综合测评指标的影响;配置不同浓度的硫酸溶液,先测定复方运脾颗粒的吸湿率并绘制吸湿平衡图,再考察复方运脾颗粒的临界相对湿度(CRH);比较提取方法、提取时间、溶媒容量对运脾颗粒中柚皮苷与橙皮苷的含量。结果:在60%的相对湿度下,以每5g浸膏粉加阿斯巴甜0.025g,加70%的乙醇0.4m L为制粒工艺条件;运脾颗粒的临界相对湿度60%;优化的提取工艺条件为称取本品颗粒0.5g,精密称定,精密加入甲醇25 m L,称定重量,水浴回流60 min。结论:该制粒工艺经济、稳定、可行,可以作为运脾颗粒制粒工艺条件;运脾颗粒制粒、分装及贮存应控制在60%的临界相对湿度以下;优化提取的工艺条件简便、稳定可行。
Objective：To investigate the molding process, the critical relative humidity （CRH）, and the extraction method of quality standards of Yunpi granule. Methods： Took granular formability, angle of repose, melting and hygroscopicity as evaluation indexes, to investigate the effect of different concentrations and different dosage of ethanol on its formable comprehensive evaluztion index by the method of single factor test. Configured different concentrations of sulfuric acid solution. First, determined the moisture absorption rate of compound Yunpi Granule and mapped its moisture balance, and then investigated the CRH of compound Yunpi Granule. Compared the contents of naringin and hesperidin in Yunpi Granule by different extraction method, extraction time and solvent volume. Results： Under the relative humidity of 60%, per 5 g extract powder added 0.025g, aspartame and 70% ethanol 0.4 mL for granulating process conditions, the CRH of Yunpi Graule was 60%. The optimized extraction technology condition was to weigh accurately 0.5g of Yunpi Granule and added precisely 25mL methanol, weighed and did water bath circumfluence for 60 min. Conclusion： The granulating technology is economical, stable and feasible, and can be used as the granulating condition of Yunpi Granule. The granulating, packing and storage of Yunpi Granule should be controlled under 60% of the critical relative humidity. The process conditions of optimized extraction is simple, stable and feasible.
出处
《贵阳中医学院学报》
2017年第1期32-37,共6页
Journal of Guiyang University of Chinese Medicine
基金
贵阳市科技计划项目
项目编号:筑科合同(2012204)46号
关键词
运脾颗粒
制粒工艺
综合评分
临界相对湿度
提取工艺研究
Yunpi Granules, granulating process, comprehensive score, critical relative humidity, extraction technology research
