摘要
细胞自噬广泛存在于真核细胞中,是细胞内的一种"自食"的现象,膜包裹部分胞质和细胞内需降解的细胞器、蛋白质等形成自噬体,并与内涵体形成自噬内涵体,在激素和溶酶体的介导下降解体内多余的蛋白质和细胞器,维持体内外内环境和神经元的稳态,对机体起到保护的作用。神经退行性疾病是一类以蛋白质异常蓄积为特点的中枢神经系统退行性疾病。近年来的研究表明,通过自噬可以有效的清除神经系统中异常积聚的蛋白质和细胞器,利用提高细胞自噬能力对神经退行性疾病进行治疗具有光明的前景,从而减轻其临床症状。
Autophagy is widely existed in eukaryotic cells,and it is a kind of ＂self food＂ phenomenon in the cell.Membrane coated part of the cytoplasm and degradation of organelles,protein which cell domestic demand,and these two forms the autophagy.They form au-tophagy endosomes with endosomes.In the hormone and lysosomal mediation,autophagy endosomes can degrade excess protein and organelles and maintain the body’s environment and neuronal homeostasisin vivo toprotect the body.Neurodegenerative disease is a kind of central nervous system degenerative disease characterized by abnormal accumulation of protein.Recent studies have shown that autophagy can effectively remove the abnormal accumulation of proteins in the nervous system and organelles.Increasing au-tophagy has a bright future for neurodegenerative diseases,thereby reducing their clinical symptoms.
出处
《世界复合医学》
2016年第4期89-91,共3页
World Journal of Complex Medicine
基金
国家自然科学基金委员会
氧化异阿扑菲衍生物对阿尔茨海默病转Aβ42基因果蝇模型的神经保护作用及其机制研究(基金号:81260496)
