摘要
目的:探讨异甘草酸镁对药物性肝炎患者的临床疗效以及对血清学指标的影响。方法:选取2013年4月—2015年9月间收治的药物性肝炎患者68例,将其随机分为观察组和对照组,每组34例;对照组患者给予甘草酸二铵治疗,观察组患者给予异甘草酸镁治疗,比较两组患者连续治疗14 d时的总有效率、血清学指标以及不良反应的发生情况。结果:观察组患者治疗后的总有效率显著高于对照组(97.06%vs 76.47%,P<0.05);治疗后观察组患者ALT、AST、TBIL、γ-GT和ALP水平均显著低于对照组(P<0.05);两组患者均无严重不良反应发生(P>0.05)。结论:异甘草酸镁用于治疗药物性肝炎患者的疗效较好,ALT下降迅速,安全性高,优于甘草酸二铵的疗效。
Objective： To investigate the influence on the clinical efficacy and serological indexes of magnesium isoglycyrrhizinate in patients with drug-induced hepatitis. Methods： 68 cases of drug-induced hepatitis during April 2013 and 2015 were randomly divided into observation group and control group（34 cases in each group）. The control group was treated with Diammonium glycyrrhizinate and the observation group was treated with magnesium isoglycyrrhizinate; the two groups were treated for 14 d. Clinical efficacy, serum indicators and adverse reactions were compared.Results： The total efficiency of the observation group was significantly higher than that of the control group （97.06% vs 76.47%, P〈0.05）. The level ofALT, AST, TBIL, γ-GT and ALP of observation group after treatment was significantly lower than that of the control group （P〈0.05）. There was no significant difference in the incidence of adverse reactions （P〉0.05）.Conelusion： Magnesium isoglycyrrhizinate in the treatment of drug-induced hepatitis has good effect with the rapid decline of aminotransferase and high safety. It can be used in clinical application.
出处
《抗感染药学》
2016年第6期1329-1331,共3页
Anti-infection Pharmacy
关键词
异甘草酸镁
甘草酸二铵
药物性肝炎
转氨酶
magnesium isoglycyrrhizinate
Diammonium glycyrrhizinate
drug-induced hepatitis
ALT
