摘要
目的探讨抗生素静脉滴注-口服序贯疗法治疗儿童肺炎临床价值。方法选择儿童肺炎140作为研究对象,按照随机分组的方式分成持续静滴组和静滴-口服组,各70例,持续静滴组常规给予止咳、祛痰等对症治疗,静脉持续滴注阿奇霉素、头孢菌素钠,静滴-口服组开始应用持续静滴组常规治疗方案,连续注射抗生素3~5天,病情缓解后停止静脉滴抗生素,改为口服相应抗生素胶囊、片剂等。结果两组热退时间分别为（5.11±0.88）天、（5.09±0.87）天、咳嗽缓解时间（4.13±0.58）天、（4.01±0.6）天、咳痰消失时间（7.87±1.98）天、（8.12±1.77）天、总有效94.29%、97.71%比较,差异无统计学意义（P〉0.05）;静滴-口服组静脉滴注抗生素（4.01±0.65）天、抗生素不良反应31.43%,均低于静滴-口服组的（11.64±1.98）天、62.86%（P〈0.05）。结论抗生素序贯治疗儿童肺炎能够得到相应的临床治疗效果的同时、缩短了静脉用药时间、减少了输液相关不良反应的发生。
Objective To investigate the clinical value of sequential therapy with intravenous infusion of antibiotics in the treatment of pneumonia in children. Methods 140 children with pneumonia as the research object,randomly divided into continuous infusion group and IV oral group 70 cases,continuous infusion group were given conventional antitussive and expectorant treatment,intravenous infusion of azithromycin,cephalosporinsodium,IV oral group began continuous intravenous application routine treatment infusion group plan,continuous injection of antibiotics 3 to 5 days after disease remission,stop intravenous antibiotics,changed to oral antibiotic capsules and tablets. Results Two groups of thermal annealing time respectively（5.11±0.88） days,（5.09±0.87） days,cough relief time（4.13±0.58） days,（4.01±0.60） days,sputum disappear time（7.87±1.98） days,（8.12±1.77） had no significant difference between the total effective 94.29%,97.71% days（P〈0.05）,IV oral group received intravenous antibiotics（4.01±0.65） days,antibiotic adverse reactions were lower than 31.43% IV oral group（11.64±1.98） days and 62.86%（P〈0.05）. Conclusion Sequential antibiotic therapy in children with pneumonia can get the corresponding clinical treatment effect at the same time,shorten the time of intravenous medication,reduce the incidence of transfusion related adverse reactions,it is worthy of clinical application.
出处
《中国继续医学教育》
2016年第34期156-158,共3页
China Continuing Medical Education
关键词
抗生素
序贯疗法
儿童肺炎
Antibiotic
Sequential therapy
Children pneumonia
