摘要
[目的]研究顺铂联合注射用黄芪多糖腹腔灌注治疗方案在胃癌合并恶性腹腔积液患者中的治疗效果。[方法]选择2012年2月~2014年2月在本院就诊的胃癌合并恶性腹腔积液患者170例,随机分为研究组与对照组。2组各85名患者,均采用常规顺铂腹腔灌注治疗方案,研究组同时联合使用注射用黄芪多糖治疗。比较2组患者治疗后治疗效果、化疗不良反应、外周血中免疫因子以及腹水中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)表达情况的差异。[结果]2组治疗后结果显示研究组腹水治疗疗效(P=0.006)、生存质量(P<0.01)、外周血CD3^+、CD4^+(P<0.01)均显著优于对照组;腹水中TNF-α、IL-6的表达较对照组降低明显(P<0.05);消化道反应(P=0.017)、白细胞减少(P=0.023)、肝功能损害(P=0.028)的发生率也较对照组明显降低。[结论]对胃癌合并恶性腹腔积液患者行顺铂腹腔灌注联合注射用黄芪多糖方案治疗能显著抑制其炎症表达,降低毒副反应的发生,提高治疗效果。
[Objective]To study the effect of Cisplatin peritoneal perfusion combined with astragalus polysaccharides（APS）injection for patients with gastric cancer and malignant ascites.[Methods]170patients with gastric cancer and malignant ascitespatients were collected in our hospital from February 2012 to February 2014 and randomly divided into two groups.Both patients received Cisplatin peritoneal perfusion,meanwhile,the study group received astragalus polysaccharides injection.The treatment effect,adverse drug reaction,immune factors in peripheral blood and the expression of IL-6and TNF-αwere compared in malignant ascites.[Results]The reasults of two groups after trearment showed that the study group has a significant increase of the malignant ascites effect（P=0.006）,quality of life（P〈0.001）,and the expression of CD3~＋,CD4~＋（P〈0.001）in peripheral blood.Meanwhile,the expression of IL-6,TNF-α（P〈0.05）,the occurrence of gastrointestinal reaction（P=0.017）,Leukopenia（P=0.023）and liver damage（P=0.028）were significantly decreased.[Conclusion]Cisplatin peritoneal perfusion combined with Astragalus polysaccharides injection can inhibit the inflammation expression,reduce the occurrence of adverse drug reaction and improve the clinical therapy effects in patients with gastric cancer and malignant ascites
作者
贾铭丽
金世柱
韩明子
JIA Ming-Li JIN Shi-zhu HAN Ming-zi(Department of Digestive, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China)
出处
《中国中西医结合消化杂志》
CAS
2016年第12期929-932,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
注射用黄芪多糖
胃癌
恶性腹水
炎性因子
astragalus polysaccharides
gastric cancer
malignant ascites
inflammation factor
