摘要
目的:探讨补肾药复方左归胶囊对于药物流产大鼠子宫内膜的修复作用,为临床用药提供实验依据。方法:采用妊娠大鼠灌服米非司酮和米索前列醇造成完全流产模型48例,随机分为空白组、西药组、祛瘀组、补肾组,于流产次日开始分别灌胃相应药物5天,用药结束后观察各组药物流产大鼠血清雌二醇(E_2)、孕酮(P)及子宫内膜组织内皮生长因子(VEGF)的变化。结果:与空白组比较,祛瘀组和补肾组VEGF和E_2的表达明显升高,西药组E_2含量明显升高,补肾组P含量明显降低,差异均有统计学意义(P<0.05,P<0.01);与西药组比较,祛瘀组和补肾组VEGF的表达明显升高,补肾组P含量降低更明显,差异均有统计学意义(P<0.05,P<0.01);与祛瘀组比较,补肾组E_2含量升高的更明显,差异有统计学意义(P<0.01)。结论:补肾药复方左归胶囊可提高药流大鼠雌激素水平,降低孕激素水平,提高子宫内膜组织VEGF含量,达到促进子宫内膜修复的作用。
Objective： To discuss mechanism of action of reinforcing kidney herbs compound zuogui capsule on improving endometrium repair after medical abortion,and provide experimental basis for clinical medication. Methods：Forty- eight pregnant rats were gavaged with mifepristone and misoprostol to established rats model of complete abortion. Divided into blank group, western medicine group,removing stasis group and kidney reinforcing group,started gavaging with corresponding drug for 5 days from the second day of abortion. After finishing medication,observed changes of estradiol（E2）,progesterone（P）,vascular endothelial cell growth factor（VEGF） of endometrium tissue in abortion rats of each group. Results：Compared with blank group,expression of VEGF and E2 in removing stasis group and kidney reinforcing group,E2 content in western medicine group were all significantly increased,P content in kidney reinforcing group was obviously decreased（P〈0.05,P〈0.01）. Compared with western medicine group,expression of VEGF and E2 in removing stasis group and kidney reinforcing group were significantly increased,P content in kidney reinforcing group was decreased more obviously（P 〈0.05, P 〈0.01）. Compared with removing stasis group, E2 content in kidney reinforcing group was increased more obviously（P〈0.01）. Conclusion：Kidney reinforcing drugs compound zuogui capsule can improve E2 repair by improving estrogen level,decreasing P level of medical abortion rats,and increasing content of VEGF of endometrium.
出处
《新中医》
CAS
2017年第2期1-3,共3页
New Chinese Medicine
