摘要
目的:探究β-七叶皂甙钠联合血塞通治疗脑血栓的机制,为脑血栓患者的临床治疗提供帮助。方法:选取新疆医科大学附属中医医院收治的92例脑血栓患者,按随机数字表法分为观察组和对照组,各46例,对照组患者采用常规治疗,观察组患者在常规治疗基础上给予β-七叶皂甙钠与血塞通的联合治疗。检测治疗前后两组患者炎症因子(IL-6、IL-10、TNF-α以及CRP)、神经细胞因子(NSE、NGF以及NTF)和血液流变学相关指标(Fg、BVH、BVL以及PV)水平。结果:两组脑血栓患者治疗前炎症因子、神经细胞因子和血液流变学相关指标比较差异无统计学差异(P>0.05)。与治疗前相比,经相关治疗后观察组和对照组患者炎症因子(IL-6、TNF-α以及CRP)、神经细胞因子NSE和血液流变学相关指标(Fg、BVH、BVL以及PV)显著降低,炎症因子IL-10与神经细胞因子(GF以及NTF)显著升高,差异存在统计学意义(P<0.05)。观察组患者经过联合治疗后炎症因子(IL-6、TNF-α以及CRP)、神经细胞因子NSE和血液流变学相关指标(Fg、BVH、BVL以及PV)显著低于治疗后对照组,炎症因子IL-10与神经细胞因子(GF以及NTF)显著高于治疗后对照组;组间差异存在统计学意义(P<0.05)。结论:β-七叶皂甙钠与血塞通联合治疗抑制了脑血栓患者的炎症反应、改善了患者的血液流动情况和促进了脑血栓患者的康复,对脑血栓患者的治疗具有十分重要的临床意义。
Objective：To observe the mechanism of sodium aescinate combined with Xuesaitong for cerebral thrombosis treatment and offer clinical help for cerebral thrombosis treatment.Methods：A total of 92 patients with cerebral thrombosis were selected and randomly divided into groups,the observation group（n=46）and the control group（n=46）.The patients in the control group were treated with conventional therapy and the patients in the observation group were treated with sodium aescinate combined with Xuesaitong on the basis of conventional therapy.Inflammatory factors（IL-6,IL-10,TNF-αand CRP）,nerve cell factor（NSE,NGF and NTF）and blood rheology indexes（Fg,BVH,BVL and PV）were detected and analyzed before and after treatment.Results：The comparison of inflammatory factors,nerve cell factor and blood rheology indexes in the two groups before treatment were not statistically significant（P〉0.05）.Inflammatory factors（IL-6,TNF-αand CRP）,nerve cell factor（NSE）and blood rheology indexes（Fg,BVH,BVL and PV）in both groups after treatment significantly decreased compared with that before treatment（P〈0.05）;inflammatory factors（IL-10）,nerve cell factor（GF and NTF）in both groups after treatment significantly increased compared with that before treatment（P〈0.05）.Inflammatory factors（IL-6,TNF-αand CRP）,nerve cell factor（NSE）and blood rheology indexes（Fg,BVH,BVL and PV）in observation group after treatment decreased more significantly than that in control group,and inflammatory factors（IL-10）,nerve cell factor（GF and NTF）increased more significantly than that in control group（P〈0.05）.Conclusions：Sodium aescinate combined with Xuesaitong could inhibit the inflammatory reaction,improve the blood flow condition and promote rehabilitation in patients with cerebral thrombosis.Therefore it has a very important clinical significance of the treatment to cerebral hemorrhage.
出处
《海南医学院学报》
CAS
2017年第2期285-288,共4页
Journal of Hainan Medical University
基金
新疆维吾尔自治区自然科学基金(2015198A136)~~
