摘要
目的探讨甲状腺良恶性结节超声造影时间-强度曲线(TIC)的差异。方法对163例患者(167枚甲状腺结节)行超声造影检查,分别绘制结节感兴趣区(ROI)和周边正常实质ROI的TIC,记录TIC形状和各造影参数,包括峰值强度(Peak)、达峰时间(Tto Pk)及曲线下面积(Area)等,并计算结节ROI减去正常实质ROI的各超声造影参数△Peak和△Area,分析不同结节大小(直径≤1 cm和>1 cm)TIC形状和定量参数的差异。结果良恶性结节在灌注相和消退相方面比较差异均有统计学意义(χ~2=36.689、16.698,P<0.01)。>1 cm的恶性结节Peak和△Area低于相同大小的良性结节(P=0.001、0.014)。≤1 cm的恶性结节Peak、Area及△Peak均低于相同大小的良性结节(P=0.008、0.001、0.005)。结论甲状腺良恶性结节TIC存在差异,有一定鉴别诊断价值。
Objective To investigate the difference of time-intensity curve（TIC）between benign and malignant thyroid nodules by contrast-enhanced ultrasound.Methods One hundred and sixty-three patients with 167 thyroid nodules（TNs）underwent contrast-enhanced ultrasound were included in this study.TIC of TNs and the adjacent thyroid parenchyma were acquired.The shape of TIC and various quantitative parameters were recorded,including peak intensity（Peak）,time to peak（Tto Pk）and the area under the curve（Area）.Then calculate the different parameter values between TNs and the adjacent thyroid parenchyma such as △Peak and △Area.The nodules were divided into group 1（≤1 cm）and group 2（1 cm）by maximum diameter.The shape of TIC and quantitative analysis findings of CEUS were compared.Results Benign and malignant TNs show different TIC patterns in wash-in and wash-out phase（χ~2=36.689,16.698,both P0.01）.Peak and Area in benign TNs were higher than those in maligant ones in group 2（P=0.001,0.014）.Area,Peak and △Peak in benign TNs were higher than those in maligant ones in group 1（P = 0. 008,0. 001,0. 005）. Conclusion TIC is different between benign and malignant TNs,and it assists in the differentiation diagnosis of TNs.
出处
《临床超声医学杂志》
2017年第1期37-40,共4页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
造影剂
时间-强度曲线
甲状腺结节
良恶性
Ultrasounography
Contrast agent
Time-intensity curve
Thyroid nodules
benign and malighant
