摘要
动脉粥样硬化是一种复杂的多因素疾病,近年来中药有效成分防治该病的作用研究已取得一定成果,而现有的防治机制研究也开始逐步深入到细胞和分子水平。TLR4信号通路可基于转录水平激活多种与炎症反应相关的细胞因子和黏附分子的表达,成为动脉粥样硬化病变机制之一。因此就近年来TLR4信号通路与动脉粥样硬化关系及中医药抗动脉粥样硬化在调节TLR4信号通路的研究进展作一综述。
Atherosclerosis （AS） is a complicated multifactor disease. In recent years, the research on Chinese medicine effective composition to prevention and treatment of AS has achieved certain results. Then existing prevention mechanism research has begun gradually to go deep into the cellular and molecular level. It＇ s one of AS pathogenesls that TLRg （Toll-like receptor 4 ） extraordinarily activates the expression of inflammation-related adhesion molecule and cytokines factors. This review discusses the TLR4 signaling pathways relationship with AS, and then discusses the experimental researches about anti-atherosclerosis mechanism of Chinese medicine by regulating the signal pathway of TLR4.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2017年第1期144-147,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
福建省科技社会发展引导性项目(2015Y0062)
关键词
动脉粥样硬化
TOLL样受体4
中药
髓样分化因子
Atherosclerosis
Toll-like receptor 4
Traditional Chinese medicine
Myeloid differentiation factor
