摘要
目的探究血流灌注用于慢性肾衰竭患者治疗对炎性指标、甲状旁腺激素和β2-微球蛋白水平的影响。方法选取该院2013年4月‐2015年6月收治的慢性肾衰竭患者102例为研究对象,采用随机双盲法原则将其分为研究组和对照组,对照组患者采用血液透析治疗,研究组患者在对照组的基础上给予血流灌注治疗,比较两组患者炎症指标[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C反应蛋白(CRP)和肿瘤坏死因子(TNF-α)]、甲状旁腺激素和β2-微球蛋白水平。结果入院时两组患者IL-1、IL-6、CRP、TNF-α、甲状旁腺激素和β2-微球蛋白水平比较差异均无统计学意义(P>0.05);治疗后所有患者均有所改善,且研究组患者改善效果显著优于对照组患者(P<0.05);治疗后两组患者炎症指标[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C反应蛋白(CRP)和肿瘤坏死因子(TNF-α)]、甲状旁腺激素和β2-微球蛋白水平比较差异均有统计学意义(P<0.05)。结论血流灌注治疗慢性肾衰竭患者,对其炎性指标、甲状旁腺素和β2-微球蛋白水平的改善效果显著,能够缓解机体炎症反应,继而促进患者康复,提高临床预后。
【Objective】To explore the effect of hemoperfusion on inflammatory markers,parathyroid hormone and β2-microglobulin levels in patients with chronic renal failure.【Methods】A total of 102 patients with chronic renal failure admitted in our hospital from April 2013 to June 2015 were selected as research objects,and were divided into the study group and the control group using a randomized double-blind principle.Fifty-one patients in the control group were treated with hemodialysis,and the study group was fed blood treatment on the basis of treatment for the control group.Inflammatory markers including interleukin-1（IL-1）,interleukin-6（IL-6）,C-reactive protein（CRP） and tumor necrosis factor-α（TNF-α）,parathyroid hormone and β2-microglobulin levels between the two groups were compared.【Results】The differences in IL-1,IL-6,CRP,TNF-α,parathyroid hormone and β2-microglobulin levels between the two groups of patients on admission were not statistically significant（P〉0.05）;after treatment,all patients were improved,and the improvement effects were significantly better in the study group than in the control group（P〈0.05）;there were statistically significant differences in inflammatory markers including interleukin-1（IL-1）,interleukin-6（IL-6）,C-reactive protein（CRP） and tumor necrosis factor-α（TNF-α）,parathyroid hormone and β2-microglobulin levels between the two groups after treatment（P〈0.05）.【Conclusion】Hemoperfusion in treating chronic renal failure has a significant effect on improving inflammatory markers as well as parathyroid hormone and β2-microglobulin levels,which can alleviate the inflammatory response,promote the rehabilitation of patients and improve clinical outcomes.
作者
彭蔚芳
张俊涛
PENG Wei-fang ZHANG Jun-tao(Department of Nephrology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, Guangdong 519000, China)
出处
《中国医学工程》
2016年第12期13-15,共3页
China Medical Engineering
