摘要
目的观察水飞蓟素胶囊联合阿托伐他汀治疗动脉粥样硬化伴高血脂症的临床疗效。方法将80例动脉粥样硬化伴高血脂症患者随机分为治疗组与对照组各40例,2组均给予常规扩血管、改善脑血流及脑代谢西药治疗,给予阿托伐他汀20 mg/d口服,治疗组在对照组治疗基础上给予水飞蓟素胶囊420 mg/d口服,治疗随访观察8周。观察2组治疗前后血脂、炎性因子(IL-6、TNF-α及CRP)、颈动脉血管彩超指标变化情况。结果治疗后2组TC、TG、LDL-C水平均较治疗前明显降低(P均<0.05),且治疗组各指标水平均明显低于对照组(P均<0.05),2组治疗前后HDL-C水平比较差异无统计学意义(P均>0.05);治疗后2组颈动脉斑块无明显消退(P均>0.05),但IMT厚度较治疗前明显降低(P均<0.05),且治疗组IMT明显低于对照组(P<0.05);治疗后2组IL-6、TNF-α及CRP水平均较治疗前明显降低(P均<0.05),且治疗组各指标水平均明显低于对照组(P均<0.05)。结论水飞蓟素胶囊联合阿托伐他汀可明显降低动脉粥样硬化伴高血脂症患者血脂水平,有助于阻断颈动脉粥样硬化患者血管斑块形成和发展,稳定动脉粥样斑块,且有较好抗炎效果,具有良好应用价值。
Objective It is to observe the clinical curative effect of Silymarin capsule with atorvastatin on atherosclerosis with hyperlipidemia. Methods 80 patients with atherosclerosis with hyperlipidemia were randomly divided into treatment group and control group,40 cases in each group. The two groups were given conventional western medicine for expansion blood vessel,improving cerebral blood flow and cerebral metabolism,and they were given atorvastatin 20 mg / d orally,the treatment group was added with Silymarin capsule 420 mg / d by oral administration on the basis of treatment in control group. Both groups were treated for 8 weeks. The changes of blood lipids,inflammatory factor（ IL-6,TNF alpha and CRP）,vascular ultrasound indicators of carotid artery before and after treatment were observed in both groups. Results The levels of TC,TG,LDL-C after treatment were significantly lower than those before treatment in both groups（ P〈0. 05）,and the level of each index of treatment group was significantly lower than that of control group（ P〈0. 05）. There was no significant difference in HDL-C before and after treatment between the two groups（ P〉0. 05）. The arotid plaques had no obvious regression after treatment in both groups（ P〉0. 05）,but the thickness of IMT was significantly lower than that before treatment（ P〈0. 05）,and IMT in treatment group was obviously lower than that in control group（ P〈0. 05）. The levels of IL-6,TNF alpha and CRP after treatment were significantly lower than those before treatment in both groups（ P〈0. 05）,and the decrease in treatment group was more significantly than that in control group（ P〈0. 05）. Conclusion Silymarin capsule with atorvastatin could obviously reduce blood lipid levels in the patients with atherosclerosis with hyperglycemia,and is helpful to block the formation and development of vascular plaque,stabilize artery atheromatous plaque,and had better anti-inflammatory effect and good application value.
出处
《现代中西医结合杂志》
CAS
2017年第7期692-694,725,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
长征医院青年启动基金项目(2016CZQN11)
