摘要
联合抗逆转录疗法(c ART)能有效抑制HIV复制和增加CD4+细胞数量,但对HIV引起的免疫活化则无明显抑制作用,持续免疫活化目前已经成为治疗AIDS的一大难题。氯喹/羟氯喹具有免疫调节功能,能抑制浆细胞样树突状细胞(p DC)活化进而有效降低免疫活化水平。此外,氯喹/羟氯喹还可通过干扰HIV包膜糖蛋白gp120糖基化抑制病毒复制及通过抑制记忆性T细胞自噬而诱导其凋亡,安全性高、毒性低,可作为一种辅助治疗药物用于HIV治疗。
Although antiretroviral therapy suppresses HIV replication,it is often unable to control immune activation in HIV infection. Immune activation is still a challenge for the cure of AIDS. Chloroquine/hydroxychloroquine is shown to have immunomodulatory property that decreases the level of immune activation by blocking activation of plasmacytoid dendritic cells（p DC）. Chloroquine/hydroxychloroquine also reduces viral replication through interfering glycoprotein 120（gp120）glycosylation and induces apoptosis by inhibiting memory T cell autophagy. Moreover,because of its safety and low toxicity,it could be proposed as an adjuvant therapy in HIV/AIDS treatment.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2017年第1期13-17,共5页
Journal of International Pharmaceutical Research
基金
国家“重大新药创制”科技重大专项资助项目(2014ZX10005-002)
国家自然科学基金资助项目(81471620
81273251
81571606)
云南省应用基础研究计划资助项目(2015FB182)
关键词
氯喹
羟氯喹
HIV
免疫活化
chloroquine
hydroxychloroquine
HIV
immune activation
