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p120ctn的表达模式与非小细胞肺癌EGFR-TKIs获得性耐药的相关性 被引量：2

The relationship between p120ctn expression pattern and acquired drug-resistance for non-small cell lung cancer EGFR-TKIs
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摘要 目的:探讨p120ctn的表达模式与非小细胞肺癌EGFR-TKIs获得性耐药的相关性。方法:应用免疫组化检测并随访具有EGFR基因突变的肺腺癌患者样本中p120ctn的表达模式,并应用Western blot检测EGFR-TKI耐药细胞系中p120ctn表达改变。结果:p120ctn异常表达的肺癌患者更容易出现获得性耐药,建立吉非替尼耐药的肺癌细胞系过程中,p120ctn的表达模式明显改变。结论:p120ctn的异常表达与肺腺癌患者的EGFR-TKIs获得性耐药相关。 Objective： To investigate the relationship between p120 ctn expression pattern and acquired drug-resistance for non-small cell lung cancer EGFR-TKIs.Methods： We used immunochemistry to examine the expression pattern of p120 ctn in patients with EGFR gene mutation,and found the different patterns of p120 ctn.Results： The patients with drug resistance are more likely to show the abnormal expression of p120 ctn.We also observed the alterations in the p120 ctn expression in gefitinib resistant lung cancer cell line.Conclusion： The expression pattern of p120 ctn is related to acquired resistance to EGFR-TKIs in NSCLC.
作者 王斯 王琳 胡晶 杜峰 刘洋
机构地区 中国医科大学基础医学院病原生物学教研室 北京市海淀区苏家坨镇社区卫生服务中心 济宁医学院基础医学院病原生物学教研室 中国医科大学基础医学院病理学教研室
出处 《现代肿瘤医学》 CAS 2017年第8期1175-1178,共4页 Journal of Modern Oncology
基金 辽宁省教育厅科学研究一般项目(编号:L2015583) 辽宁省科学计划项目(编号:2013408001)
关键词 P120-CATENIN 肺癌 EGFR-TKIS 获得性耐药 p120-catenin lung cancer EGFR-TKIs acquired resistance
分类号 R734.2 [医药卫生—肿瘤]
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现代肿瘤医学
2017年 第8期

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