摘要
肌肉减少症和骨质疏松是影响老年人健康常见的两种疾病，在多方面存在共性，肌肉和骨骼作为这两种疾病的病变组织，在解剖、生理、病理方面均存在密切的联系。最初使用宏观的机械刺激解释两者之间的关系，现深入至细胞分子机制，两者均可以分泌多种生长因子、细胞因子、多肽等，肌源性因子包括成纤维细胞生长因子-2、肌生成抑制蛋白、鸢尾素、白介素、胰岛素样生长因子-1、肌肉素等，骨源性因子包含骨钙素、成纤维细胞生长因子-2、胰岛素样生长因子-1、血管内皮生长因子等。本文就这些因子在肌肉、骨骼相互影响中的作用进行综述。
Sarcopenia and osteoporosis are two common diseases with adverse effects on the health of the elderly and share many characteristics. As target organs of the two diseases,muscles and bones are closely connected, not only in anatomy and physiology, but also in pathophysiological processes. Initially,mechanical stimulation was conducted to explain the relationship between muscle and bone at the macroscopic level. Currently, research is increasingly focused at the cellular and molecular levels. Both muscle and bone tissues can secrete a number of growth factors, cytokines, polypeptides, and so on. Myokines include fibroblast growth factor 2 （FGF-2）, myostatin, irisin, insulin like growth factor 1 （IGF-1）, interleukins, musclin, among others. Osteokines comprise osteocalcin, fibroblast growth factor-23, IGF-1, vascular endothelial growth factor, etc. In this review, we summarize the roles of myokines and osteoklnes in muscle-bone interactions.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2017年第3期344-347,共4页
Chinese Journal of Geriatrics
基金
国家临床重点专科建设项目[国卫办医函（2013）544号]
重庆地区老年人群肌肉减少症流行病学调查及危险因素筛查[渝卫科教发（2015MSXM016）]
关键词
肌疾病
骨质流松
Muscular diseases
Osteoporosis
