摘要
目的初步观察及评价化疗后细胞因子诱导的杀伤细胞(CIK)序贯治疗老年急性髓系白血病(AML)患者的临床疗效,为老年AML患者建立新的副作用较小的维持治疗方法。方法以5例多疗程化疗后疾病达缓解或部分缓解后难以继续耐受化疗的老年AML患者为研究对象,辅以自体CIK细胞序贯治疗。观察分析5例患者CIK细胞输注后一般症状及不良反应,细胞免疫功能状态、外周血微小残留病变(MRD)水平、生活质量评分(KPS)及生存期。结果 5例患者共接受35次CIK细胞回输过程中均未出现不良反应,回输后患者精神、食欲、体力等较前改善。CIK细胞治疗后调节T细胞与效应T细胞比例(2.70±1.59)较CIK细胞输注前(5.35±5.50)明显降低(P<0.05)。CIK细胞治疗后患者外周血MRD[(0.16±0.30)%]较CIK细胞治疗前MRD[(0.86±0.84)%]明显降低(P<0.05)。CIK细胞输注后患者KPS评分(88.8±6.03)较输注前(75.45±10.35)改善(P<0.05),平均总生存期29.8个月。结论本研究5例老年AML患者化疗后自体CIK细胞序贯维持治疗安全有效。
Objective To preliminary observe and evaluate the clinical effectiveness of autologous cytokine-induced killer（CIK） cells sequential therapy after chemotherapy of elderly patients with acute myeloid leukemia（AML）, then build a new maintenance therapeutic method with less side effects for AML. Methods Five elderly patients with AML were selected as the research objects, who achieved complete remission or partial remission have weak tolerance to continue chemotherapy. The five patients＇ general symptoms and adverse reaction, cellular immune function, peripheral blood micro resist disease （MRD） lever, living quality and survival of five patients were ob- served and analyzed after CIK cells infusion. Results The results showed that no adverse reaction appeared in the 35 cycles CIK cells infusion for 5 patients. After the infusion 5 patients＇ spirit, appetite, physical strength were improved. After the CIK infusion, the percentage of regulate T cells and effect T cells 2.70 ± 1.59 was reduced compared with 5.35±5.50 before the CIK infusion （P 〈0. 05）. After the CIK infusion the level of MRD（0. 16 ±0. 30） % was significantly reduced compared with （0. 86 ± 0. 84） % before the CIK infusion （ P 〈 0. 05 ）. After the CIK infusion the goal of KPS 88.8 ±6.03 was ameliorate than 75.45 ± 10. 35 before the CIK infusion （P 〈 0. 05 ）. Five patients＇ overall survival （OS） was 29.8 months. Conclusion Autologous CIK cells sequential maintenance therapy is safe and effective for the eider patients with AML.
出处
《安徽医科大学学报》
CAS
北大核心
2017年第3期412-416,共5页
Acta Universitatis Medicinalis Anhui
基金
国家自然科学基金(编号:81401293)
安徽高校省级自然科学研究重大项目(编号:KJ2014ZD17)
