摘要
病毒样颗粒是指利用异源宿主系统表达的病毒,结构蛋白自行组装成不含病毒基因组、不能复制、不具有感染能力的病毒样蛋白颗粒。病毒样颗粒具备构象逼真、安全、稳定、可刺激体液和细胞免疫应答、作为载体表达其他抗原以及可设计成区分自然感染与免疫接种等诸多优点。有研究表明,新城疫病毒样颗粒可用来研制针对新城疫流行变异株的高效疫苗。作者就新城疫病毒样颗粒相关研究进展进行较为详尽的综述,以期为中国新城疫病毒样颗粒疫苗的研究提供参考。
The virus like-particles（VLPs）is the virus like protein particles,expressed by a heterologous host system,use viral structural proteins to assemble themselves,non viral genome,can not be copied,have no infection ability.Virus like-particles has many advantages such as realistic conformation,safe,stable,can stimulate humoral and cellular immune responses,as a carrier to express other antigens and can be designed to distinguish between natural infection and vaccination.Some studies have indicated that the Newcastle disease virus particles can be used to develop a vaccine against Newcastle disease.In this paper,the author makes a detailed review on the research progress of Newcastle disease virus particles,in order to provide reference for the study of the vaccine of Newcastle disease virus like-particles in China.
出处
《畜牧兽医杂志》
2017年第2期19-20,共2页
Journal of Animal Science and Veterinary Medicine
关键词
新城疫病毒
病毒样颗粒
疫苗
Newcastle Disease Virus
Virus-like particles
Vaccine
