摘要
目的 探讨黄芪注射液联合低分子肝素、硝苯地平对子痫前期患者相关指标水平及妊娠结局的影响。方法 选取慈溪市妇幼保健院2013年3月～2016年12月期间收治的60例子痫前期患者,随机分为研究组和对照组,每组各30例。均给予解痉、利尿等常规治疗,对照组给予低分子肝素、硝苯地平治疗,研究组加用黄芪注射液干预。治疗前后监测2组血压、凝血功能等实验室指标水平,并统计2组妊娠并发症发生情况及妊娠结局。结果 2组治疗前血压、人绒毛膜促性腺激素（β-h CG）、妊娠甲胎蛋白（AFP）及凝血功能各项指标水平比较差异无统计学意义,治疗后血压、β-hCG、AFP、血小板计数（PLT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、血浆纤维蛋白原（FIB）及D-二聚体（D-D）均显著改善,差异有统计学意义（P〈0.05）,且治疗后研究组舒张压、收缩压、β-hCG、AFP、PLT、FIB、D-D水平均明显低于对照组,差异有统计学意义（P〈0.05）,PT、APTT明显较对照组延长,差异有统计学意义（P〈0.05）。研究组宫缩乏力、胎膜早破、胎儿宫内窘迫、胎盘早剥等妊娠并发症发生率及剖宫产、新生儿窒息等不良妊娠结局发生率明显低于对照组,差异有统计学意义（P〈0.05）。结论 黄芪注射液联合低分子肝素、硝苯地平用于子痫前期患者的临床治疗,可有效调节血压等指标水平,降低妊娠并发症,改善妊娠结局。
Objective To investigate the effect of Astragalus injection combined with low molecular weight heparin and nifedipine on levels of related indexes and pregnancy outcomes in patients with preeclampsia.Methods A total of 60 patients with preeclampsia from March 2013 to December 2016 in Cixi Municipal Maternal and Child Care Hospital were selected and randomly divided into the study group and control group, with 30 cases in each group.All patients were given spasmolysis, diuretic and other conventional treatment.The control group were treated with low molecular weight heparin and nifedipine while the study group were additionally treated with Astragalus injection.The blood pressure, blood coagulation and other laboratory indicators in the two groups were monitored before and after treatment , and the incidence of pregnancy complications and pregnancy outcomes in the two groups were statistically analyzed.Results There was no significant difference in blood pressure, human chorionic gonadotropin （β-hCG）, alpha fetoprotein （AFP） and blood coagulation function indexes in the two groups before treatment .After treatment, the blood pressure,β-hCG, AFP, platelet count （PLT）, prothrombin time （PT）, activated partial thromboplastin time （APTT）, plasma fibrinogen （FIB） and D-dimer （D-D） were significantly improved, the difference was statistically significant （ P〈0.05）.After treatment, the diastolic and systolic blood pressure, β-hCG, AFP, PLT, FIB and D-D levels in the study group were significantly lower than those in the control group, the difference was statistically significant （ P〈0.05）, PT and APTT were significantly longer than those in the control group, the difference was statistically significant （P〈0.05）.The incidence rates of pregnancy complications （ uterine inertia, premature rupture of membrane, fetal distress, placental abruption） and adverse pregnancy outcomes （cesarean section, neonatal asphyxia） in the study group were significantly lower than those in the control group, the difference was statistically significant （P〈0.05）.Conclusion The application of Astragalus injection combined with low molecular weight heparin and nifedipine in the clinical treatment of patients with preeclampsia can effectively control the blood pressure level and other parameters , reduce pregnancy complications and improve pregnancy outcomes.
出处
《中国生化药物杂志》
CAS
2017年第3期162-164,167,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
子痫前期
黄芪注射液
妊娠
血压
妊娠结局
preeclampsia
Astragalus injection
pregnancy
blood pressure
pregnancy outcome
