摘要
目的:探讨过敏性紫癜(Henoch-Schoenlein purpura,HSP)患者急性期血清中IL-34的表达及意义。方法:选取HSP患者38例,同期匹配的健康人21例作为对照组,采用酶联免疫吸附法(ELISA)及化学发光法检测血清中IL-34、IL-6、TNF-α表达水平;采用相关分析法分析IL-34与患者临床资料指标的关系以及与IL-6、TNF-α表达的相关性。结果:HSP患者急性期血清IL-34、IL-6、TNF-α水平均较正常对照组增高,差异具有统计学意义(P<0.001);血清IL-34和超敏C反应蛋白(hsCRP)、IL-6水平之间呈正相关(分别是r=0.453,P=0.004;r=0.469,P=0.003)。结论:IL-34可能参与过敏性紫癜的致病过程;可能与过敏性紫癜促炎因子的异常表达有关,促进血管炎症的发生发展。
Objective： To investigate the serum level of IL-34 in patients with acute phase Henoch-Schoenlein purpura（ HSP）and its potential significance. Methods： 38 HSP patients were recruited,together with 21 healthy volunteers as control. The serum level of IL-34,IL-6 and TNF-α were determined using enzyme-linked immunosorbent assay（ ELISA） or chemiluminescence. The correlation analysis was performed to explore the correlation of IL-34 with clinical parameters and the serum level of IL-6,TNF-α. Results： The serum levels of IL-34,IL-6 and TNF-α in HSP patients were significantly higher as compared to the control group（ P〈0. 001）. The serum level of IL-34 was positively correlated with that of high sensitive C-reactive protein（ hs-CRP） and IL-6（ r = 0. 453,P = 0. 004 and r =0. 469,P = 0. 003,respectively）. Conclusion： IL-34 might be involved in the pathogenesis of HSP,and the potential mechanisms of action is associated with the aberrant expression of pro-inflammatory factors in HSP,which promote the development of inflammation in the vascular system.
作者
王娟
夏海龙
WANG Juan XIA Hai-Long(Department of Hematology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022, Chin)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2017年第3期433-436,共4页
Chinese Journal of Immunology
