摘要
念珠菌是引起严重黏膜感染和系统性感染的重要真菌,但不是所有个体都有感染念珠菌的风险。随着人类基因组计划的完成以及分子遗传技术的发展,人们开始从基因角度研究真菌感染的易感性。研究发现一些原发性免疫缺陷如STAT1、STAT3或CARD9缺陷与严重的念珠菌感染有关;此外,部分与免疫相关的基因多态性与念珠菌感染(如复发性外阴阴道念珠菌病和念珠菌血症等疾病)的易感性相关。念珠菌易感基因的发现可以更好地了解疾病的发病机制,同时为临床诊治念珠菌感染提供新的检测指标和治疗靶标。
Candida spp.are medically important fungi causing severe mucosal and systemic infections,however,not all individuals are at risk to develop Candidainfections.With the completion of the human genome project and the development of molecular genetic technology,the genentic susceptibility to Candidainfections has attracted the attention of more and more researchers.Severe fungal infections are associated with monogenic primary immunodeficiencies such as defects in STAT1,STAT3 or CARD9.Furthermore,some polymorphisms in genes of the immune system have also been associated with fungal infections such as recurrent vulvovaginal candidiasis and candidemia.The discovery of the genetic susceptibility to Candida infections can lead to a better understanding of the pathogenesis of the disease,as well as the development of novel detection index and therapeutic target.
出处
《中国真菌学杂志》
CSCD
2017年第2期120-123,共4页
Chinese Journal of Mycology
基金
国家自然科学基金(81573059)
关键词
念珠菌感染
基因易感性
原发性免疫缺陷病
基因多态性
Candidainfections
genetic susceptibility
primary immunodeficiency diseases
gene polymorphisms
