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白念珠菌与生物膜相关的耐药机制 被引量:9

The resistance mechanisms of the biofilm related Candida albicans
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摘要 白念珠菌在医疗植入材料上形成生物膜,导致高死亡率感染。成熟的生物膜具有强耐药性,使得生物膜相关感染难以治愈。文章主要从白念珠菌生物膜外排泵基因、细胞外基质以及压力应答等3个方面探讨白念珠菌生物膜的耐药机制,综述该研究方向的最新进展,为白念珠菌的临床防治策略制定提供参考。 Candida albicans can form biofilms on medical implant materials, leading to high mortality infection. Mature biofilm related C.albicans infections are difficult to cure because of multi-drug resistance.This review discusses the resistance mechanisms of biofilm related C.albicans from efflux pump genes and matrix and stress response, summarizing the research advance of the mechanism and providing reference for clinical prevention strategies.
出处 《中国真菌学杂志》 CSCD 2017年第2期124-127,共4页 Chinese Journal of Mycology
基金 上海市科委基金(15ZR1426900) 上海市医学重点专科(ZK2012A21) 上海市黄浦区优秀青年人才(RCPY1407)
关键词 白念珠菌 生物膜 耐药机制 细胞外基质 Candida albicans biofilm resistance mechanism matrix
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  • 1Cateau E, Berjeaud JM, Rodier MH,et al. Fungal biofilm inhibition by a component naturally produced by Candida albicans yeasts growing as a biofilm [ J ]. Int J Antimicrob Agents, 2008 ,31 (2) : 166 - 170.
  • 2Finkel JS, Mitchell AP. Genetic control of Candida albicans biofilm de- velopment [ J ]. Nat Rev Microbiol, 2011,9 (2) : 109 - 118.
  • 3Ramage G, Vandewalle K, Wickes BL, et al. Characteristics of biofilm formation by Candida albicans [ J ]. Rev Iberoam Micol,2001,18 (4) : 163 - 170.
  • 4Hasan F, Xess I, Wang X, et al. Biofilm formation in clinical Candida isolates and its association with virulence [ J ]. Microbes Infect, 2009, 11(8 -9) : 753 -761.
  • 5Pierce CG, Uppuluri P, Tummala S, et al. A 96 well microtiter plate- based method for monitoring formation and antifungal susceptibility tes- ting of Candida albicans biofilms[J]. J Vis Exp, 2010, (44) : 2287.
  • 6Chandra J, Mukherjee PK, Leidich SD. Antifungal resistance of can- didal biofilrns formed on denture acrylic in vitro[ J]. J Dent Res ,2001 , 80(3 ) :903 -908.
  • 7Andes D, Nett J, Oschel P, et al. Development and characterization of an in vivo central venous catheter Candida albicans biofilm[ J ]. Model. Infect Immun, 2004 , 72(10): 6023-6031.
  • 8Uppuluri P, Pierce CG, Lopez-Ribot JL. Candida albicans Biofilm For- mation and its Clinical Consequenees[ J]. Future Mierobiol, 2009 , 4 (10) : 1235 -1237.
  • 9Douglas LJ. Penetration of antifugal agents through Candida biofilms [ J]. Methods Mol Biol, 2009,499:37 -44.
  • 10Chandra J, Kuhn DM, Mukherjee PK, et al. Biofilm formation by the fungal pathogen Candida albicans development, architecture, and drug resistance[ J]. J Bacteriol,2001 , 183 ( 18 ) :5385 - 5394.

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