摘要
目的了解昭通市女性宫颈感染人乳头瘤病毒(HPV)感染率和基因型的分布情况.方法采用流式荧光杂交法对昭通市第一人民医院妇科门诊就诊的5 430例女性进行HPV基因分型检测,同时对92例患者进行宫颈活检病理学检查.结果 5 430例女性中HPV阳性705例,感染率为12.98%:其中单一亚型感染554例(78.58%),混合亚型感染151例(21.42%),其中双重感染106例(15.04%),三重感染38例(5.39%),四重感染5例(0.71%),五重感染2例(0.28%).在单一阳性感染病例中,主要为高危亚型感染,占总检出标本的60.85%型(429/705);低危亚型感染17.73%(125/705).低级别CIN组患者中,以HPV52感染最多,而高级别的CIN组患者中,则HPV16感染最多.结论昭通市HPV病毒感染阳性率12.98%,基因分型以HPV52最多,其次为HPV16、81、53、58型,HPV16感染在宫颈癌的发病中具有重要作用,通过检测HPV病毒及早发现高危型HPV感染,及早干预、治疗,阻止病程发展有重要意义.
Objective To understand the infection rate of human papillomavirus（HPV） and the distribution of HPV genotype in female cervix in Zhaotong city. Me thods 5 430 female patients in the outpatient section of gynaecology of our hospital were given HPV genotyping test with the method of Flowcytometry Fluorescence hybridization. At the same time, 92 patients were given cervical biopsy pathological examination. Re s ult 705 out of 5 340 cases were HPV positive, and the infection rate was 12.98%; 554 cases（78.58%） were infected with a single subtype, 151 cases（21.42%） infected with mixed subtype, among which 106 cases（15.04%） were double infection, 38cases（5.39%） triple infection, 5 cases（0.71%） fourfold and 2 cases（0.28%）fivefold infection. In the cases of single positive infection, high-risk subtypes infection accounts for 60.85%（429/705） and low risk subtype infection accounts for 17.73%（125/705）. HPV 52 infection patient take up most in low grade cervical intraepithelial neoplasia group, while HPV16 infection patients take up most in the high grade cervical intraepithelial neoplasia group. Conclus ion The positive rate of HPV virus infection in Zhaotong city was12.98%, and the most of genotyoe was HPV52, followed by HPV16, 81, 53, 58. HPV16 infection has an important role in the pathogenesis of cervical cancer. It is of critical importance to discover high-risk HPV infection through detecting HPV virus,to intervene and to treat it at an early stage.
出处
《昆明医科大学学报》
CAS
2017年第2期90-94,共5页
Journal of Kunming Medical University
基金
云南省教育厅科学研究基金资助项目(2014C028Y)
关键词
宫颈疾病
人乳头瘤病毒
感染
研究
Cervical disease
Human papilloma virus
Infected
Research
