摘要
目的探讨疏血通对急性脑梗塞患者血流动力学和血清可溶性细胞间粘附分子-1(soluble intercellular adhersion molecule-1,s ICAM-1)、白介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的影响.方法将2011年1月至2015年1月清涧县人民医院收治的100例急性脑梗塞患者随机分为观察组和对照组,其中对照组患者50例,给予常规药物进行治疗,观察组50例,在给予常规药物治疗的同时静脉滴注疏血通注射液进行治疗.观察2组患者治疗前后脑血流动力学指标变化,并采用酶联免疫吸附实验(enzyme linked immunosorbent assay,ELISA)检测血清s ICAM-1、IL-6、TNF-α的表达水平.结果脑血流动力学指标比较,治疗后对照组脑血流动力学指标改变不显著,差异无统计学意义(P>0.05),而观察组患者治疗后各血流动力学指标较同组治疗前以及对照组治疗后均有明显改善,差异具有统计学意义(P<0.05).血清s ICAM-1、IL-6、TNF-α水平比较,2组患者治疗后血清s ICAM-1、IL-6、TNF-α水平较治疗前均有明显降低(P<0.01);且治疗后观察组血清s ICAM-1、IL-6、TNF-α水平又显著低于同期对照组,差异均具有统计学意义(P<0.01).结论疏血通注射液可有效改善急性脑梗塞患者血流动力学指标,降低患者血清s ICAM-1、IL-6、TNF-α的表达,对脑梗塞的治疗有积极作用.
Objective To investigate the effects of Shuxuetong on hemodynamics and serum s ICAM-1,IL-6,TNF-α in patients with cerebral infarction. Methods A hundred patients with cerebral infarction were randomly divided into observation group and control group from Jan 2011 to Jan 2015. Fifty patients in control group were treated with conventional therapy alone and 50 patients in observation group were treated with conventional therapy combined with intravenous injection with Shuxuetong. The changes of hemodynamics were observed before and after treatment and the levels of serum s ICAM-1, IL-6, TNF-α were detected by enzyme linked immunosorbent assay（ELISA）. Results No statistical significance was found in hemodynamics of control groupbefore and after treatment（P〈0.05）. The indexes of hemodynamics in observation group were significantly improved compared with those in observation group before treatment and those in control group after treatment（P〈0.05）. The levels of serum sI CAM-1, IL-6, TNF-α were significantly reduced in two groups after treatment（P〈0.01） and the levels of serum sI CAM-1, IL-6, TNF-α after treatment were significantly lower in observation group than those in control group（P〈0.01）. Conclusion Shuxuetong can effectively improve the indexes of hemodynamics and reduce the levels of serum sI CAM-1, IL-6 and TNF-α. It has a positive effect on the treatment of cerevral infarction.
作者
白润爱
康娟
古联
BAI Run-ai KANG Juan(Dept. of lnternal Medicine, People＇s Hospital of Qingjian, Yulin Shctanxi 718300 ） Dept. of Neurology, Xijing Hospital Affiliated to The Fourth Military Medical University, Xi＇an Shaanxi 710032Guangxi Traditional Chinese Medical University, Nanning Guangxi 530000, China)
出处
《昆明医科大学学报》
CAS
2016年第9期58-61,共4页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81260594)
