摘要
目的调查桂西地区女性的人乳头瘤病毒(HPV)的宫颈感染现状及基因型分布特点。方法收集3 315例宫颈脱落细胞标本,采用凯普导流杂交进行HPV基因分型检测,对受检者感染结果进行统计分析。结果 HPV总感染率是21.30%(706/3 315),HPV阳性感染者中,以高危型感染为主,占89.52%(632/706)。HPV感染型别中,以单一型感染为主,占72.66%(513/706),二重感染占22.10%(156/706)。21种HPV亚型均有被检出,HPV高危亚型检出率较高的有HPV52(26.77%)、HPV16(15.30%)、HPV58(15.01%)。HPV低危亚型检出率较高的是HPV CP8304(11.90%)、HPV6(3.68%)。不同年龄段妇女的HPV亚型分布有差异,在≤20、>20~30、>30~40、>40~50、>50~60、>60~70、>70岁7个年龄段中,高危型HPV感染率分别是21.62%(8/37)、19.26%(120/623)、17.66%(220/1246)、14.88%(153/1028)、16.83%(51/303)、15.52%(9/58)、30.00%(6/20),各组间差异无统计学意义(χ~2=10.019,P=0.124)。结论桂西地区女性宫颈HPV感染主要以高危型、单一感染为主,感染率较高的HPV亚型依次是HPV52、16、58及CP8304。
Objective To investigate the infection status quo and genotype distribution of human papillomavirus(HPV)infection situation among females in west Guangxi area.Methods Cervical exfoliative cells samples from 3 315 women were collected to detect HPV genotyping with Cape flow-through hybridization.Then the results were statistically analyzed.Results The overall HPV infection rate was 21.30%(706/3 315),in the females of HPV positive infection,the high-risk type infection was predominant,accounting for 89.52%(632/706).The HPV infection type was dominated by single type infection,accounting for 72.66%the double infection accounted for 22.10%(156/706).The 21 HPV subtypes were detected.The high-risk HPV subtypes with high detection rate were HPV52(26.77%),HPV16(15.30%)and HPV58(15.01%).The low-risk HPV subtypes with high detection rate were HPV CP8304(11.90%)and HPV6(3.68%).The HPV subtypes were distributed differently at different ages.In 7age groups of≤20,>20-30,>30-40,>40-50,>50-60,>60-70,>70years old,the infection rates of high risk HPV were21.62%(8/37),19.26%(120/623),17.66%(220/1 246),14.88%(153/1 028),16.83%(51/303),15.52%(9/58)and 30.00%(6/20)respectively,showing no statistically significant differences among them(χ2=10.019,P=0.124).Conclusion Cervical HPV infection are mainly high-risk HPV subtypes and single type infection in females of western Guangxi area.The HPV subtypes with high infection rate are 52,16,58 and CP8304.
出处
《国际检验医学杂志》
CAS
2017年第9期1192-1195,共4页
International Journal of Laboratory Medicine
关键词
人乳头瘤病毒
宫颈病变
基因型
广西
human papillomaviruses
cervical lesions
genotypes
Guangxi
