摘要
最近研究表明阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是支气管哮喘急性加重的独立危险因素。OSAHS常涉及睡眠时上气道吸气气流受限及气道塌陷,常与日间症状如嗜睡、抑郁、精力难以集中等相关。支气管哮喘常表现为气道慢性炎症、气道高反应、可逆性气道气流受限等。现已有大量学者对其相关性作出研究,但未达成统一共识。目前认为神经反射因素、胃食管反流、气道及全身炎症反应、睡眠结构紊乱、肥胖、心血管疾病、激素治疗及鼻部疾病等可能是OSAHS与哮喘相互影响及作用的机制。本文就OSAHS与哮喘的相关性及其机制作一综述。
Recent studies have suggested that obstructive sleep apnea hypopnea syndrome （OSAHS） is an independent risk factor for acute exacerbation of bronchial asthma.OSAHS commonly involves inhaled airflow limitation and upper airway collapse during sleep, and is usually associated with some daytime symptoms such as sleepiness, depression, poor concentration, and so on.Bronchial asthma is usually manifested as chronic inflammation, hyperresponsiveness and reversable airflow limitation of airway.So far, many researchers have investigated this association, however, no consensus has been reached.It is generally regarded that following factors are involved in the interaction mechanisms of OSAHS and asthma, that is, neural reflection, gastroesophageal reflux, airway and general inflammatory response, sleep structure disturbance, obesity, cardiovascular diseases, oral steroid use, nasal disorders, and so on.This article reviewed the association between OSAHS and asthma and its mechanisms.
作者
陈佳娣
张希龙
孙培莉
CHEN Jia-Di ZHANG Xi-Long SUN Pei-Li(Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China)
出处
《中华老年多器官疾病杂志》
2017年第4期304-307,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
江苏省呼吸病临床医学研究中心项目(BL2012012)~~
