摘要
目的 分析阿托伐他汀联合双抗血小板对缺血性急性脑卒中患者再发血管事件的获益及风险.方法 选取2012年9月至2014年9月缺血性急性脑卒中患者106例,随机分为观察组与对照组,每组53例,给予对照组患者氯吡格雷联合阿司匹林双抗血小板治疗,观察组在对照组治疗基础上再联合阿托伐他汀治疗.比较两组患者临床治疗有效率,比较治疗前后三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等血脂水平及颈动脉管腔直径、收缩期峰值血流速度（SV）、舒张期峰值血流速度（DV）、阻力指数（RI）等颈动脉硬化指标水平,比较两组患者治疗后再发血管事件及不良反应的发生率.结果 观察组临床治疗总有效率为90.57%,显著高于对照组的75.47%（P〈0.05）;治疗后观察组TC、TG、LDL-C水平显著低于对照组,HDL-C水平显著高于对照组（P〈0.05）;观察组颈动脉管腔直径、SV、DV显著高于对照组（P〈0.05）,RI显著低于对照组（P〈0.05）;观察组再发血管事件发生率为3.77%,显著低于对照组的16.98%（P〈0.05）;观察组不良反应发生率为5.66%,显著低于对照组的20.75%（P〈0.05）.结论 阿托伐他汀联合双抗血小板治疗缺血性急性脑卒中疗效显著,患者的血脂水平及颈动脉硬化指标水平得到有效改善,再发血管事件和不良反应发生率显著降低,值得临床应用推广.
Objective To analyze the benefit and risk of atorvastatin combined with dual antiplatelet therapy on recurrence vascular events in patients with acute ischemic stroke.Methods One hundred and six patients with acute ischemic stroke from September 2012 to September 2014 were selected, they were divided into the observation group and the control group （each of 53 cases）, the control group was given clopidogrel combined with aspirin dual antiplatelet therapy, the observation group added atorvastatin therapy on the basis of the control group.The clinical treatment efficiency of the two groups were compared, triacylglycerol （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） and other blood lipid levels, and carotid lumen diameter, peak systolic blood flow velocity （SV）, peak diastolic velocity （DV）, resistance index （RI） and other carotid artery atherosclerosis indexes before and after the treatment were compared, the incidences of recurrence vascular events and adverse reactions in the two groups after the treatment were compared.Results The total effective rate in the observation group（90.57%） was significantly higher than that in the control group （75.47%, P〈0.05）;TC, TG, LDL-C levels in the observation group after the treatment were significantly lower than those in the control group, HDL-C level was significantly higher than that in the control group （P〈0.05）;carotid lumen diameter, SV, DV in the observation group were significantly higher than those in the control group （P〈0.05）, RI was significantly lower than that in the control group （P〈0.05）;the incidence of recurrence vascular events in the observation group （3.77%） was significantly lower than that in the control group （16.98%, P〈0.05）;the incidence of adverse reactions in the observation group （5.66%） was significantly lower than that in the control group （20.75%, P〈0.05）.Conclusions Curative effect of atorvastatin combined with dual antiplatelet therapy on acute ischemic stroke is distinct, it can improve the blood lipid levels and carotid artery atherosclerosis indexes level of patients effectively, reduce incidence of recurrence vascular events and adverse reactions significantly, so it is worth using in clinical practice.
出处
《中国实用医刊》
2017年第8期19-22,共4页
Chinese Journal of Practical Medicine
