摘要
目的:评价血必净注射液对慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床肺部感染评分(Clinical pulmonary infection score,CPIS)、炎症标记物及免疫功能的影响以及其临床疗效。方法:将78例AECOPD患者随机分为两组(治疗组和对照组),每组均为39例,两组均予常规抗炎、解痉平喘、祛痰治疗,治疗组加用生理盐水250 m L+血必净注射液100 m L 1次/d静脉滴注,疗程为10 d。观察两组的临床疗效、记录治疗前后两组患者的CPIS评分并检测患者血清中炎症标记物(C反应蛋白CRP、降钙素原PCT、白细胞总数WBC)及免疫功能(CD_3、CD_4、CD_8、CD_4/CD_8)的变化。结果:治疗后,治疗组与对照组患者所有观察指标均较治疗前明显改善(P<0.05)。治疗后除白细胞总数差异无统计学意义外(P>0.05),治疗组在治疗后总有效率、CRP、PCT、CD_3、CD_4、CD_8、CD_4/CD_8均明显优于对照组,且差异具有统计学意义(P<0.05)。结论:临床应用血必净注射液协同治疗AECOPD,能提高患者免疫功能,减轻炎症反应,明显提高治疗有效率。
Objective ：To evaluate the clinical effects of Xuebijing Injection on CPIS scores and inflammatory markers and inmmne function of patients with AECOPD. Methods ： A total of 78 patients with AECOPD were randomly divided into two groups ：38 cases in the treatment group and 38 cases in the control group. All patients received the conventional treat- ments including anti - infection, antispasmodic, anti - asthmati, expeetoranttherapyand 100mL Xuebijing Injection with NS 250mL（once a day, ten days for a course） were added in the treatment group. The changes of serum CD3 , CD4 , CD8, CD4/CD8 and CRP,PCT and WBC were tested. The curative effect and clinical pulmonary infection scores were observed for ten days. Result ： After the full course of treatment, the treatment group and the control group＇ s indicatorswere all ob- served and significantly improved （ P 〈 0. 05 ）. After treatment, there was no significant difference in the total white blood cell count （P 〉 0. 05）. After treatment, the total effective rates, such asCRP, PCT, CD3 , CD4 , CDs and CDo/CDs were significantly better than the control group＇ s, showing significant difference （ P 〈 O. 05 ）. Conclusion ： Clinical application of Xuebijing Injection synergistic treatment of AECOPDcan improve the immune function of patients, reduce inflammation and significantly improve the efficiency of treatment.
出处
《中华中医药学刊》
CAS
北大核心
2017年第5期1240-1242,共3页
Chinese Archives of Traditional Chinese Medicine
基金
辽宁省科技厅项目(2011225016)
关键词
血必净注射液
慢性阻塞性肺疾病加重期
CPIS评分
炎症标记物
免疫功能
疗效观察
Xuebijing Injection
acute exacerbation of chronic obstructive pulmonary disease
CPIS
inflammation marker
immunologic function
efficacy observation
